PolyBall: A new adsorbent for the efficient removal of endotoxin from biopharmaceuticals.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
20 06 2019
20 06 2019
Historique:
received:
25
02
2019
accepted:
06
06
2019
entrez:
22
6
2019
pubmed:
22
6
2019
medline:
21
10
2020
Statut:
epublish
Résumé
The presence of endotoxin, also known as lipopolysaccharides (LPS), as a side product appears to be a major drawback for the production of certain biomolecules that are essential for research, pharmaceutical, and industrial applications. In the biotechnology industry, gram-negative bacteria (e.g., Escherichia coli) are widely used to produce recombinant products such as proteins, plasmid DNAs and vaccines. These products are contaminated with LPS, which may cause side effects when administered to animals or humans. Purification of LPS often suffers from product loss. For this reason, special attention must be paid when purifying proteins aiming a product as free as possible of LPS with high product recovery. Although there are a number of methods for removing LPS, the question about how LPS removal can be carried out in an efficient and economical way is still one of the most intriguing issues and has no satisfactory solution yet. In this work, polymeric poly-ε-caprolactone (PCL) nanoparticles (NPs) (d
Identifiants
pubmed: 31222053
doi: 10.1038/s41598-019-45402-w
pii: 10.1038/s41598-019-45402-w
pmc: PMC6586805
doi:
Substances chimiques
Biological Products
0
Caproates
0
Lactones
0
Lipopolysaccharides
0
caprolactone
56RE988L1R
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8867Références
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