A familial chromosomal complex rearrangement confirms RUNX1T1 as a causative gene for intellectual disability and suggests that 1p22.1p21.3 duplication is likely benign.

1p22.1p21.3 duplication 8q21.3q22.1 deletion Complex chromosomal rearrangements RUNX1T1

Journal

Molecular cytogenetics
ISSN: 1755-8166
Titre abrégé: Mol Cytogenet
Pays: England
ID NLM: 101317942

Informations de publication

Date de publication:
2019
Historique:
received: 25 02 2019
accepted: 04 06 2019
entrez: 22 6 2019
pubmed: 22 6 2019
medline: 22 6 2019
Statut: epublish

Résumé

Complex chromosomal rearrangements are constitutive structural aberrations involving three or more breaks. They can be balanced or unbalanced and result in different outcomes, depending on deletion/duplication of genomic material, gene disruption, or position effects. We report on a patient presenting with severe anemia, splenomegaly, mild intellectual disability and facial dysmorphisms harboring a 4.3 Mb duplication at 1p22.1p21.3 and a 2.1 Mb deletion at 8q21.3q22.1, involving RUNX1T1 gene. The healthy brother presented the same duplication of chromosome 1p as at 1p22.1p21.3. The rearrangement found both these siblings resulted from malsegregation in the proband and recombination in her healthy brother of a balanced paternal complex chromosomal rearrangement. These results confirm RUNX1T1 as a causative gene for intellectual disability and suggest the 1p22.1p21.3 duplication is likely benign.

Sections du résumé

BACKGROUND BACKGROUND
Complex chromosomal rearrangements are constitutive structural aberrations involving three or more breaks. They can be balanced or unbalanced and result in different outcomes, depending on deletion/duplication of genomic material, gene disruption, or position effects.
CASE PRESENTATION METHODS
We report on a patient presenting with severe anemia, splenomegaly, mild intellectual disability and facial dysmorphisms harboring a 4.3 Mb duplication at 1p22.1p21.3 and a 2.1 Mb deletion at 8q21.3q22.1, involving RUNX1T1 gene. The healthy brother presented the same duplication of chromosome 1p as at 1p22.1p21.3.
CONCLUSIONS CONCLUSIONS
The rearrangement found both these siblings resulted from malsegregation in the proband and recombination in her healthy brother of a balanced paternal complex chromosomal rearrangement. These results confirm RUNX1T1 as a causative gene for intellectual disability and suggest the 1p22.1p21.3 duplication is likely benign.

Identifiants

pubmed: 31223340
doi: 10.1186/s13039-019-0440-6
pii: 440
pmc: PMC6570965
doi:

Types de publication

Case Reports

Langues

eng

Pagination

26

Déclaration de conflit d'intérêts

Competing interestsThe authors declare that they have no competing interests.

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Auteurs

Fabrizia Restaldi (F)

Bambino Gesù Children's Hospital, Rome, Italy.

Viola Alesi (V)

Bambino Gesù Children's Hospital, Rome, Italy.

Angela Aquilani (A)

Bambino Gesù Children's Hospital, Rome, Italy.

Silvia Genovese (S)

Bambino Gesù Children's Hospital, Rome, Italy.

Serena Russo (S)

Bambino Gesù Children's Hospital, Rome, Italy.

Valentina Coletti (V)

Bambino Gesù Children's Hospital, Rome, Italy.

Daniele Pompili (D)

Bambino Gesù Children's Hospital, Rome, Italy.

Roberto Falasca (R)

Bambino Gesù Children's Hospital, Rome, Italy.

Bruno Dallapiccola (B)

Bambino Gesù Children's Hospital, Rome, Italy.

Rossella Capolino (R)

Bambino Gesù Children's Hospital, Rome, Italy.

Matteo Luciani (M)

Bambino Gesù Children's Hospital, Rome, Italy.

Antonio Novelli (A)

Bambino Gesù Children's Hospital, Rome, Italy.

Classifications MeSH