Pilot Study of Circulating Tumor Cells in Early-Stage and Metastatic Uveal Melanoma.
circulating tumor cells
liquid biopsy
pilot study
uveal melanoma
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
20 Jun 2019
20 Jun 2019
Historique:
received:
11
05
2019
revised:
07
06
2019
accepted:
18
06
2019
entrez:
23
6
2019
pubmed:
23
6
2019
medline:
23
6
2019
Statut:
epublish
Résumé
Nearly 50% of uveal melanoma (UM) patients develop metastatic disease, and there remains no current standard assay for detection of minimal residual disease. We conducted a pilot study to check the feasibility of circulating tumor cell (CTC) detection in UM. We enrolled 40 patients with early or metastatic UM of which 20 patients had early-stage disease, 19 had metastatic disease, and one was not evaluable. At initial blood draw, 36% of patients had detectable CTCs (30% in early-stage vs. 42% in metastatic), which increased to 54% at data cutoff (40% in early-stage vs. 68% in metastatic). Five early-stage patients developed distant metastases, 60% (3/5) had detectable CTCs before radiographic detection of the metastasis. Landmark overall survival (from study enrollment) at 24 months was statistically lower in CTC-positive vs. negative early-stage UM (
Identifiants
pubmed: 31226786
pii: cancers11060856
doi: 10.3390/cancers11060856
pmc: PMC6628316
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : Skin spore Grant number 10750
Pays : United States
Références
JCO Precis Oncol. 2018 May 17;2:
pubmed: 32913999
Clin Cancer Res. 2004 Mar 1;10(5):1605-12
pubmed: 15014010
Arch Ophthalmol. 2009 Aug;127(8):989-98
pubmed: 19667335
Cancer Discov. 2016 May;6(5):479-91
pubmed: 26969689
Nat Biotechnol. 2013 Jun;31(6):539-44
pubmed: 23609047
Cancer. 2018 Jul 1;124(13):2693-2703
pubmed: 29579316
Br J Ophthalmol. 2015 Nov;99(11):1550-3
pubmed: 25904122
Science. 2013 Sep 13;341(6151):1186-8
pubmed: 24031008
Invest Ophthalmol Vis Sci. 2014 Jun 26;55(7):4395-404
pubmed: 24970258
Pigment Cell Melanoma Res. 2016 Sep;29(5):583-9
pubmed: 27390171
Int J Cancer. 2014 Mar 1;134(5):1207-13
pubmed: 23934701
Eye (Lond). 2017 Feb;31(2):241-257
pubmed: 27911450
Genome Med. 2011 May 31;3(5):31
pubmed: 21631906
Cancer. 1998 Oct 15;83(8):1664-78
pubmed: 9781962
Acta Ophthalmol. 2011 Feb;89(1):17-24
pubmed: 21272286
Clin Cancer Res. 2007 Feb 15;13(4):1171-8
pubmed: 17317826
Ophthalmology. 2011 Sep;118(9):1881-5
pubmed: 21704381