Is It Possible to Predict the Odor of a Molecule on the Basis of its Structure?
flavor
odor
odorant
olfaction
olfactory sense
sensory perception
structure-function relationship
volatile organic compounds
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
20 Jun 2019
20 Jun 2019
Historique:
received:
29
05
2019
revised:
17
06
2019
accepted:
18
06
2019
entrez:
23
6
2019
pubmed:
23
6
2019
medline:
18
12
2019
Statut:
epublish
Résumé
The olfactory sense is the dominant sensory perception for many animals. When Richard Axel and Linda B. Buck received the Nobel Prize in 2004 for discovering the G protein-coupled receptors' role in olfactory cells, they highlighted the importance of olfaction to the scientific community. Several theories have tried to explain how cells are able to distinguish such a wide variety of odorant molecules in a complex context in which enantiomers can result in completely different perceptions and structurally different molecules. Moreover, sex, age, cultural origin, and individual differences contribute to odor perception variations that complicate the picture. In this article, recent advances in olfaction theory are presented, and future trends in human olfaction such as structure-based odor prediction and artificial sniffing are discussed at the frontiers of chemistry, physiology, neurobiology, and machine learning.
Identifiants
pubmed: 31226833
pii: ijms20123018
doi: 10.3390/ijms20123018
pmc: PMC6627536
pii:
doi:
Substances chimiques
Receptors, Odorant
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Education, Audiovisual and Culture Executive Agency
ID : 600873-EPP-1-2018-1ES-EPPKA2-KA
Références
Angew Chem Int Ed Engl. 2000 Sep 1;39(17):2980-3010
pubmed: 11028024
Biochim Biophys Acta. 2000 Oct 18;1482(1-2):229-40
pubmed: 11058764
J Med Chem. 2001 Aug 16;44(17):2805-13
pubmed: 11495591
Chem Rev. 1996 Dec 19;96(8):3201-3240
pubmed: 11848858
Chem Senses. 2003 Jan;28(1):57-69
pubmed: 12502524
Nature. 1954 Oct 9;174(4432):693-4
pubmed: 13213982
Nature. 1961 Sep 23;191:1310-1
pubmed: 13873066
Nature. 1963 Apr 20;198:271-2
pubmed: 14012641
Protein Sci. 2004 Jan;13(1):240-54
pubmed: 14691239
Chem Senses. 2004 May;29(4):269-90
pubmed: 15150141
Angew Chem Int Ed Engl. 2006 Sep 25;45(38):6254-61
pubmed: 16983730
Eur Arch Otorhinolaryngol. 2007 Mar;264(3):237-43
pubmed: 17021776
Trends Neurosci. 2007 Feb;30(2):47-53
pubmed: 17161473
Mol Neurobiol. 2007 Apr;35(2):175-81
pubmed: 17917106
PLoS Biol. 2007 Oct 30;5(11):e284
pubmed: 17973576
Cell. 1991 Apr 5;65(1):175-87
pubmed: 1840504
J R Soc Interface. 2009 Jan 6;6(30):75-86
pubmed: 18595834
PLoS One. 2008 Jul 09;3(7):e2640
pubmed: 18612420
Chem Biodivers. 2008 Jun;5(6):862-86
pubmed: 18618409
Behav Brain Res. 2009 Jun 8;200(1):68-75
pubmed: 19162085
Commun Integr Biol. 2009 May;2(3):279-81
pubmed: 19641751
Cell. 2009 Oct 2;139(1):45-59
pubmed: 19804753
J Med Life. 2009 Apr-Jun;2(2):196-8
pubmed: 20108540
Exp Brain Res. 2010 Aug;205(1):13-29
pubmed: 20603708
Prog Mol Biol Transl Sci. 2010;94:213-40
pubmed: 21036327
J Cell Biol. 2010 Nov 1;191(3):443-52
pubmed: 21041441
J Neurosci. 2010 Dec 1;30(48):16391-8
pubmed: 21123585
Biochemistry. 2011 Feb 8;50(5):843-53
pubmed: 21142015
Eur Ann Otorhinolaryngol Head Neck Dis. 2011 Jan;128(1):18-23
pubmed: 21227767
Anal Chem. 1998 Apr 1;70(7):1440-3
pubmed: 21644739
J Neurosci. 2011 Jun 22;31(25):9179-91
pubmed: 21697369
Sensors (Basel). 2012;12(4):4105-12
pubmed: 22666021
PLoS One. 2013;8(3):e59547
pubmed: 23555703
EMBO Rep. 2013 Oct;14(10):874-83
pubmed: 24030282
Int J Environ Res Public Health. 2013 Nov 25;10(12):6273-91
pubmed: 24287852
Front Psychol. 2014 Feb 07;5:20
pubmed: 24570664
Otolaryngol Pol. 2014 Nov-Dec;68(6):308-14
pubmed: 25168274
Eur Arch Otorhinolaryngol. 2015 Aug;272(8):1937-44
pubmed: 25238811
Proc Natl Acad Sci U S A. 2015 May 26;112(21):E2766-74
pubmed: 25901328
Protein Sci. 2015 Sep;24(9):1543-8
pubmed: 26044705
J Am Chem Soc. 2015 Jul 8;137(26):8611-8616
pubmed: 26090619
Cortex. 2015 Dec;73:180-7
pubmed: 26457822
Int J Mol Sci. 2015 Nov 30;16(12):28320-33
pubmed: 26633363
Chem Senses. 2016 Feb;41(2):105-21
pubmed: 26688501
Bull Acad Natl Med. 2014 Jun;198(6):1109-20; discussion 1120-2
pubmed: 26983189
Mol Inform. 2013 Oct;32(9-10):855-65
pubmed: 27480237
Chem Senses. 2017 Jan;42(1):37-46
pubmed: 27655940
J Neurosci. 2017 Feb 8;37(6):1428-1438
pubmed: 28028200
Mil Med Res. 2017 Mar 15;4:9
pubmed: 28344819
Curr Opin Insect Sci. 2017 Apr;20:34-38
pubmed: 28428935
Science. 2017 May 12;356(6338):
pubmed: 28495701
Curr Med Chem. 2019;26(1):197-215
pubmed: 28982314
Biosystems. 2018 Feb;164:94-101
pubmed: 29054468
Curr Biol. 2018 Feb 5;28(3):R108-R110
pubmed: 29408254
Front Endocrinol (Lausanne). 2018 Jan 23;8:379
pubmed: 29410650
Sci Adv. 2018 Feb 09;4(2):eaao6086
pubmed: 29487905
Food Res Int. 2018 Jul;109:138-148
pubmed: 29803435
Chem Senses. 2018 Nov 1;43(9):667-695
pubmed: 30256909
Sensors (Basel). 2018 Sep 27;18(10):null
pubmed: 30262737
Chem Senses. 2019 Jan 1;44(1):11-22
pubmed: 30371751
J Agric Food Chem. 2018 Dec 26;66(51):13346-13366
pubmed: 30453735
eNeuro. 2018 Dec 26;5(5):
pubmed: 30596145
PLoS One. 2018 Dec 31;13(12):e0206517
pubmed: 30596674
Elife. 2019 Jan 17;8:null
pubmed: 30652684
Sensors (Basel). 2019 Jan 30;19(3):null
pubmed: 30704021
Front Psychol. 2019 Feb 13;10:242
pubmed: 30814965
eNeuro. 2019 Feb 28;6(1):
pubmed: 30834302
eNeuro. 2019 Feb 27;6(1):
pubmed: 30834303
Int J Mol Sci. 2019 Apr 02;20(7):null
pubmed: 30986990
Proc Natl Acad Sci U S A. 2019 May 7;116(19):9475-9480
pubmed: 31040214
J Gen Physiol. 1970 Jul;56(1):46-63
pubmed: 5514160
Nature. 1968 Feb 3;217(5127):423-7
pubmed: 5641754
Science. 1984 Dec 21;226(4681):1441-3
pubmed: 6505700
Nature. 1982 Sep 23;299(5881):352-5
pubmed: 7110356
Crit Rev Biochem Mol Biol. 1994;29(3):199-228
pubmed: 8070277
J Chem Inf Comput Sci. 1996 Jan-Feb;36(1):108-13
pubmed: 8576286