Protocol for a double-blind placebo-controlled trial to evaluate the efficacy of probiotics in reducing antibiotics for infection in care home residents: the Probiotics to Reduce Infections iN CarE home reSidentS (PRINCESS) trial.
antibiotic resistance
antibiotic use
care home
flu
infection
probiotics
Journal
BMJ open
ISSN: 2044-6055
Titre abrégé: BMJ Open
Pays: England
ID NLM: 101552874
Informations de publication
Date de publication:
20 06 2019
20 06 2019
Historique:
entrez:
23
6
2019
pubmed:
23
6
2019
medline:
9
6
2020
Statut:
epublish
Résumé
Care home residents are at increased risk of infections and antibiotic prescription. Reduced antibiotic use from fewer infections would improve quality of life. The PRINCESS is a double-blind, individually randomised, placebo-controlled trial that will assess the effect of a daily oral probiotic combination of Ethics approval is from the Wales Research Ethics Committee 3. Findings will be disseminated through peer-reviewed journals and conferences; results will be of interest to patient and policy stakeholders. ISRCTN16392920; Pre-results.
Identifiants
pubmed: 31227535
pii: bmjopen-2018-027513
doi: 10.1136/bmjopen-2018-027513
pmc: PMC6596947
doi:
Substances chimiques
Anti-Bacterial Agents
0
Banques de données
ISRCTN
['ISRCTN16392920']
Types de publication
Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e027513Subventions
Organisme : Department of Health
ID : EME/13/95/10
Pays : United Kingdom
Organisme : Medical Research Council
Pays : United Kingdom
Informations de copyright
© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: PCC reports grants from National Institute for Health Research, grants from EME Programme funded by NIHR / MRC. During the conduct of the study PCC receives personal fees from Christian Hansen, and non-financial support from Christian Hansen outside the submitted work.
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