PD-L1 expression on nonclassical monocytes reveals their origin and immunoregulatory function.
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
21 06 2019
21 06 2019
Historique:
received:
08
11
2017
revised:
01
02
2019
accepted:
20
05
2019
entrez:
23
6
2019
pubmed:
23
6
2019
medline:
16
5
2020
Statut:
ppublish
Résumé
The role of nonclassical monocytes (NCMs) in health and disease is emerging, but their location and function within tissues remain poorly explored. Imaging of NCMs has been limited by the lack of an established single NCM marker. Here, we characterize the immune checkpoint molecule PD-L1 (CD274) as an unequivocal marker for tracking NCMs in circulation and pinpoint their compartmentalized distribution in tissues by two-photon microscopy. Visualization of PD-L1
Identifiants
pubmed: 31227596
pii: 4/36/eaar3054
doi: 10.1126/sciimmunol.aar3054
pii:
doi:
Substances chimiques
Antibodies
0
B7-H1 Antigen
0
Cd274 protein, mouse
0
Immunoglobulin G
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.