MEN1309/OBT076, a First-In-Class Antibody-Drug Conjugate Targeting CD205 in Solid Tumors.
Animals
Antibodies, Monoclonal
/ chemistry
Antigens, CD
/ immunology
CHO Cells
Cell Line, Tumor
Cricetulus
Female
HEK293 Cells
HT29 Cells
Humans
Immunoconjugates
/ chemistry
Lectins, C-Type
/ antagonists & inhibitors
MCF-7 Cells
Maytansine
/ chemistry
Mice
Mice, Nude
Mice, SCID
Minor Histocompatibility Antigens
/ immunology
Molecular Targeted Therapy
/ methods
Neoplasms
/ drug therapy
Receptors, Cell Surface
/ antagonists & inhibitors
Xenograft Model Antitumor Assays
/ methods
Journal
Molecular cancer therapeutics
ISSN: 1538-8514
Titre abrégé: Mol Cancer Ther
Pays: United States
ID NLM: 101132535
Informations de publication
Date de publication:
09 2019
09 2019
Historique:
received:
10
07
2018
revised:
16
01
2019
accepted:
17
06
2019
pubmed:
23
6
2019
medline:
18
6
2020
entrez:
23
6
2019
Statut:
ppublish
Résumé
CD205 is a type I transmembrane glycoprotein and is a member of the C-type lectin receptor family. Analysis by mass spectrometry revealed that CD205 was robustly expressed and highly prevalent in a variety of solid malignancies from different histotypes. IHC confirmed the increased expression of CD205 in pancreatic, bladder, and triple-negative breast cancer (TNBC) compared with that in the corresponding normal tissues. Using immunofluorescence microscopy, rapid internalization of the CD205 antigen was observed. These results supported the development of MEN1309/OBT076, a fully humanized CD205-targeting mAb conjugated to DM4, a potent maytansinoid derivate, via a cleavable N-succinimidyl-4-(2-pyridyldithio) butanoate linker. MEN1309/OBT076 was characterized
Identifiants
pubmed: 31227646
pii: 1535-7163.MCT-18-0624
doi: 10.1158/1535-7163.MCT-18-0624
doi:
Substances chimiques
Antibodies, Monoclonal
0
Antigens, CD
0
DEC-205 receptor
0
Immunoconjugates
0
Lectins, C-Type
0
Minor Histocompatibility Antigens
0
Receptors, Cell Surface
0
Maytansine
14083FR882
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1533-1543Informations de copyright
©2019 American Association for Cancer Research.