A single amino acid change in hemagglutinin reduces the cross-reactivity of antiserum against an equine influenza vaccine strain.
Amino Acid Substitution
Animals
Antibodies, Viral
/ immunology
Cross Reactions
Hemagglutinin Glycoproteins, Influenza Virus
/ administration & dosage
Horse Diseases
/ immunology
Horses
Immune Sera
/ immunology
Influenza A virus
/ genetics
Influenza Vaccines
/ administration & dosage
Orthomyxoviridae Infections
/ immunology
Journal
Archives of virology
ISSN: 1432-8798
Titre abrégé: Arch Virol
Pays: Austria
ID NLM: 7506870
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
24
02
2019
accepted:
27
05
2019
pubmed:
23
6
2019
medline:
17
8
2019
entrez:
23
6
2019
Statut:
ppublish
Résumé
Equine influenza virus is an important pathogen for the horse industry because of its economic impact, and vaccination is a key control measure. Our previous work suggested that a mutation at position 144 in the hemagglutinin of Florida sublineage clade 2 viruses reduces the cross-neutralizing activity of antiserum against a former vaccine strain. To confirm this suggestion, here, we generated viruses by reverse genetics. Antibody titers against the mutated viruses were one-tenth to one-sixteenth of those against the former vaccine strain. Our findings confirm that this single amino acid substitution reduces the cross-reactivity of antiserum against this former Japanese vaccine.
Identifiants
pubmed: 31227892
doi: 10.1007/s00705-019-04328-4
pii: 10.1007/s00705-019-04328-4
doi:
Substances chimiques
Antibodies, Viral
0
Hemagglutinin Glycoproteins, Influenza Virus
0
Immune Sera
0
Influenza Vaccines
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM