Rat Models of Metabolic Syndrome.

Animals Cholesterol / metabolism Disease Models, Animal Genetic Predisposition to Disease Lipoproteins, HDL / metabolism Metabolic Syndrome / etiology Rats Rats, Inbred Strains
Hypertension MetS Metabolic syndrome Obesity Rat disease model Rat genetic model Rat inbred model

Journal

Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969

Informations de publication

Date de publication:
2019
Historique:
entrez: 23 6 2019
pubmed: 23 6 2019
medline: 14 11 2019
Statut: ppublish

Résumé

Metabolic syndrome is a complex disorder that comprises several other complex disorders, including obesity, hypertension, dyslipidemia, and diabetes. There are several rat models that encompass component features of MetS. Some models are inbred strains selected for one or more traits underlying MetS; others are population models with genetic risk for MetS traits, are induced by environmental stressors such as diet, are spontaneous monogenic mutant models, or are congenic strains derived from a combination of these models. Together they can be studied to identify the genetic and physiological underpinnings of MetS to identify candidate genes or mechanisms for study in human MetS subjects.

Identifiants

DOI: 10.1007/978-1-4939-9581-3_13 PMID: 31228162 PMC: PMC7315404
pubmed: 31228162
doi: 10.1007/978-1-4939-9581-3_13
pmc: PMC7315404
mid: NIHMS1601913
doi:

Substances chimiques

Lipoproteins, HDL 0
Cholesterol 97C5T2UQ7J

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

269-285

Subventions

Organisme : NHLBI NIH HHS
ID : R01 HL064541
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL089895
Pays : United States
Organisme : NIDDK NIH HHS
ID : R21 DK089417
Pays : United States

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Auteurs

Anne E Kwitek (AE)

Department of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA. akwitek@mcw.edu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Rat Models of Metabolic Syndrome.
questionsmedicales.fr › Lipides › Lipides membranaires › Stérols › Cholestérol › Rat Models of Metabolic Syndrome.
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Rat Models of Metabolic Syndrome.
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Rat Models of Metabolic Syndrome.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Lipoprotéines HDL › Rat Models of Metabolic Syndrome.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Syndrome métabolique X › Rat Models of Metabolic Syndrome.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Models of Metabolic Syndrome.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Lignées consanguines de rats › Rat Models of Metabolic Syndrome.