Muscle derangement and alteration of the nutritional machinery in NSCLC.
Body composition
Muscle wasting
Non-small cell lung cancer
Nutritional status
Weight loss
Journal
Critical reviews in oncology/hematology
ISSN: 1879-0461
Titre abrégé: Crit Rev Oncol Hematol
Pays: Netherlands
ID NLM: 8916049
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
19
03
2019
revised:
08
06
2019
accepted:
09
06
2019
pubmed:
23
6
2019
medline:
18
10
2019
entrez:
23
6
2019
Statut:
ppublish
Résumé
Weight loss and depletion of nutritional status are frequent presentation hallmarks in non-small cell lung cancer (NSCLC). Decline in muscle mass is a major component in weight loss and may have both a prognostic and predictive value for survival and treatment-related toxicities. Recent findings suggest that weight and skeletal muscle mass gain during treatment may represent surrogate markers for outcome in advanced NSCLC patients. Herein we present an in-depth view of the impact of nutritional status derangements on NSCLC patients' outcome, focusing on lean body mass variations during disease course. We explored the impact of malnutrition with a major attention on novel treatment options. We reviewed molecular, metabolic and immunological mechanisms underlying muscle-wasting condition, which may exhibit a meaningful targeting potential. Incorporating a specialized and accurate body composition assessment into a comprehensive, patient-centered and tailored intervention will facilitate the achievement of nutritional goals and optimal care for lung cancer patients.
Identifiants
pubmed: 31228648
pii: S1040-8428(19)30123-4
doi: 10.1016/j.critrevonc.2019.06.007
pii:
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
43-53Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.