Paradoxical lucidity: A potential paradigm shift for the neurobiology and treatment of severe dementias.

Alzheimer Disease Cognition / physiology Dementia Humans
Alzheimer's disease Cognition Consciousness Dementia End-of-life care Lucidity Recovery

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
08 2019
Historique:
received: 04 01 2019
revised: 26 03 2019
accepted: 03 04 2019
pubmed: 24 6 2019
medline: 4 8 2020
entrez: 24 6 2019
Statut: ppublish

Résumé

Unexpected cognitive lucidity and communication in patients with severe dementias, especially around the time of death, have been observed and reported anecdotally. Here, we review what is known about this phenomenon, related phenomena that provide insight into potential mechanisms, ethical implications, and methodologic considerations for systematic investigation. We conclude that paradoxical lucidity, if systematically confirmed, challenges current assumptions and highlights the possibility of network-level return of cognitive function in cases of severe dementias, which can provide insight into both underlying neurobiology and future therapeutic possibilities.

Identifiants

DOI: 10.1016/j.jalz.2019.04.002 PMID: 31229433
pubmed: 31229433
pii: S1552-5260(19)30095-0
doi: 10.1016/j.jalz.2019.04.002
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

1107-1114

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

George A Mashour (GA)

Center for Consciousness Science, Neuroscience Graduate Program, Department of Anesthesiology, University of Michigan, Ann Arbor, MI, USA. Electronic address: gmashour@umich.edu.

Lori Frank (L)

RAND Corporation, Arlington, VA, USA.

Alexander Batthyany (A)

International Academy of Philosophy, University in the Principality of Liechtenstein, Viktor Frankl Chair, Mauren, Principality of Liechtenstein.

Ann Marie Kolanowski (AM)

College of Nursing, Pennsylvania State University, University Park, PA, USA.

Michael Nahm (M)

Institute for Frontier Areas of Psychology and Mental Health, Freiburg, Germany.

Dena Schulman-Green (D)

Yale School of Nursing, West Haven, CT, USA.

Bruce Greyson (B)

Department of Psychiatry, University of Virginia, Charlottesville, VA, USA.

Serguei Pakhomov (S)

Department of Pharmaceutical Care and Health Systems, University of Minnesota, Minneapolis, MN, USA.

Jason Karlawish (J)

Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA; Department of Medical Ethics and Health Policy, University of Pennsylvania, Philadelphia, PA, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.

Raj C Shah (RC)

Department of Family Medicine, Rush Medical College, Chicago, IL, USA.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Paradoxical lucidity: A potential paradigm...
questionsmedicales.fr › Phénomènes psychologiques › Processus mentaux › Cognition › Paradoxical lucidity: A potential paradigm...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Paradoxical lucidity: A potential paradigm...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Paradoxical lucidity: A potential paradigm...