ComBATing aging-does increased brown adipose tissue activity confer longevity?
Aging
Brown adipose tissue
Metabolism
Thermogenesis
Journal
GeroScience
ISSN: 2509-2723
Titre abrégé: Geroscience
Pays: Switzerland
ID NLM: 101686284
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
02
05
2019
accepted:
30
05
2019
pubmed:
24
6
2019
medline:
14
4
2020
entrez:
24
6
2019
Statut:
ppublish
Résumé
Brown and its related beige adipose tissue (BAT) play a definitive role in maintaining body temperature by producing heat through uncoupling protein 1 (UCP1), which acts by dissociating oxidative phosphorylation from ATP production, resulting in the release of heat. Therefore, in order to maintain high thermogenic capacity, BAT must act as a metabolic sink by taking up vast amounts of circulating glucose and lipids for oxidation. This, along with the rediscovery of BAT in adult humans, has fueled the study of BAT as a putative therapeutic approach to manage the growing rates of obesity and metabolic syndromes. Notably, many of the beneficial consequences of BAT activity overlap with metabolic biomarkers of extended lifespan and healthspan. In this review, we provide background about BAT including the thermogenic program, BAT's role as a secretory organ, and differences between BAT in mice and humans. We also provide details on BAT during aging, and perspectives on the potential of targeting BAT to promote lifespan and healthspan.
Identifiants
pubmed: 31230192
doi: 10.1007/s11357-019-00076-0
pii: 10.1007/s11357-019-00076-0
pmc: PMC6702504
doi:
Substances chimiques
Blood Glucose
0
Lipids
0
Uncoupling Protein 1
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
285-296Subventions
Organisme : NIH HHS
ID : T32DK007260
Pays : United States
Organisme : NIH HHS
ID : R01DK102898
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK102898
Pays : United States
Organisme : NIH HHS
ID : P30DK036836
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK007260
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK036836
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK077097
Pays : United States
Organisme : NIH HHS
ID : R01DK077097
Pays : United States
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