The effect of hyperglycinemic treatment in captive-bred Vervet monkeys (Chlorocebus aethiops).

Animals Chlorocebus aethiops Dextromethorphan / therapeutic use Glycine / blood Hyperglycinemia, Nonketotic / blood Sodium Benzoate / therapeutic use Treatment Outcome
Dextromethorphan Glycine Sodium benzoate Spontaneous hyperglycinemia Valproate and Vervet monkey

Journal

Metabolic brain disease
ISSN: 1573-7365
Titre abrégé: Metab Brain Dis
Pays: United States
ID NLM: 8610370

Informations de publication

Date de publication:
10 2019
Historique:
received: 24 10 2018
accepted: 10 06 2019
pubmed: 24 6 2019
medline: 1 5 2020
entrez: 24 6 2019
Statut: ppublish

Résumé

Nonketotic hyperglycinemia (NKH) is a neuro-metabolic disorder caused by a deficiency in the glycine cleavage system (GCS) and glycine transporter 1 (GlyT1). A case of atypical late onset of NKH has been reported in a colony of captive-bred Vervet monkeys. The purpose of this study was to evaluate the effect of sodium benzoate and dextromethorphan in reducing glycine levels in hyperglycinemic monkeys. Twelve captive-bred Vervet monkeys were assigned into three groups consisting of four animals (control, valproate induced and cataract with spontaneous hyperglycinemia). Valproate was used to elevate glycine levels and the induced group was then treated with sodium benzoate and dextromethorphan together with group three to normalise glycine levels in cerebrospinal fluid (CSF) and plasma. Valproate induction elicited changes in phosphate, alkaline phosphatase and platelet count, however, no significant changes in the glycine levels were observed, and this might be due to the individual variability within the group. The treatment intervention was only obtained in the spontaneous group whereby the glycine levels were normalised in CSF and plasma. Therefore, it can be concluded that sodium benzoate and dextromethorphan treatment was effective and beneficial to the hyperglycinemic group.

Identifiants

DOI: 10.1007/s11011-019-00449-6 PMID: 31230217
pubmed: 31230217
doi: 10.1007/s11011-019-00449-6
pii: 10.1007/s11011-019-00449-6
doi:

Substances chimiques

Dextromethorphan 7355X3ROTS
Sodium Benzoate OJ245FE5EU
Glycine TE7660XO1C

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1467-1472

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Auteurs

Zandisiwe E Magwebu (ZE)

Primate Unit and Delft Animal Centre, South African Medical Research Council, P.O Box 19070, Tygerberg, Cape Town, 7505, South Africa. zandisiwe.magwebu@mrc.ac.za.
ORCID: 0000-0003-4861-6018

Mikateko Mazinu (M)

Primate Unit and Delft Animal Centre, South African Medical Research Council, P.O Box 19070, Tygerberg, Cape Town, 7505, South Africa.

Sahar Abdul-Rasool (S)

Medical Bioscience Department, University of the Western Cape, Belville, South Africa.

Chesa G Chauke (CG)

Primate Unit and Delft Animal Centre, South African Medical Research Council, P.O Box 19070, Tygerberg, Cape Town, 7505, South Africa.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The effect of hyperglycinemic treatment in...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Cercopithecidae › Cercopithecinae › Cercopithecus › Cercopithecus aethiops › The effect of hyperglycinemic treatment in...
questionsmedicales.fr › Composés polycycliques › Hydrocarbures aromatiques polycycliques › Phénanthrènes › Morphinanes › Dextrométhorphane › The effect of hyperglycinemic treatment in...
questionsmedicales.fr › Acides aminés, peptides et protéines › Acides aminés › Glycine › The effect of hyperglycinemic treatment in...
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Maladies métaboliques › Erreurs innées du métabolisme › Encéphalopathies métaboliques congénitales › Hyperglycinémie non cétosique › The effect of hyperglycinemic treatment in...
questionsmedicales.fr › Composés chimiques organiques › Hydrocarbures › Hydrocarbures cycliques › Hydrocarbures aromatiques › Dérivés du benzène › Benzoates › Acide benzoïque › Benzoate de sodium › The effect of hyperglycinemic treatment in...
questionsmedicales.fr › Qualité, accès, évaluation des soins de santé › Qualité des soins de santé › Mécanismes d'évaluation des soins de santé › Évaluation des résultats et des processus en soins de santé › Évaluation de résultat (soins) › Résultat thérapeutique › The effect of hyperglycinemic treatment in...