Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisal.
Calcium channels
bipolar affective disorders
novel central nervous system drugs
psychiatry
therapy
Journal
The British journal of psychiatry : the journal of mental science
ISSN: 1472-1465
Titre abrégé: Br J Psychiatry
Pays: England
ID NLM: 0342367
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
pubmed:
25
6
2019
medline:
10
4
2021
entrez:
25
6
2019
Statut:
ppublish
Résumé
We reappraise the psychiatric potential of calcium channel blockers (CCBs). First, voltage-gated calcium channels are risk genes for several disorders. Second, use of CCBs is associated with altered psychiatric risks and outcomes. Third, research shows there is an opportunity for brain-selective CCBs, which are better suited to psychiatric indications.
Identifiants
pubmed: 31230606
pii: S0007125019001570
doi: 10.1192/bjp.2019.157
pmc: PMC7557861
doi:
Substances chimiques
Calcium Channel Blockers
0
Calcium Channels
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
250-253Subventions
Organisme : Wellcome Trust
ID : 206279/Z/17/Z
Pays : United Kingdom
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