Dynamic Podosome-Like Structures in Nascent Phagosomes Are Coordinated by Phosphoinositides.
Actins
/ genetics
Female
Humans
Integrins
/ genetics
Male
Microscopy, Fluorescence
Microscopy, Interference
Monocytes
Phagocytosis
/ genetics
Phagosomes
/ genetics
Phosphatidylinositol Phosphates
/ genetics
Phosphatidylinositols
/ genetics
Podosomes
/ genetics
Pseudopodia
/ genetics
Receptors, Fc
/ genetics
Surface Properties
Arp2/3
PI(3,4,5)P3
PI(4,5)P2
integrin
phagocytosis
phosphoinositide
podosome
Journal
Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028
Informations de publication
Date de publication:
19 08 2019
19 08 2019
Historique:
received:
11
09
2018
revised:
10
03
2019
accepted:
10
05
2019
pubmed:
25
6
2019
medline:
16
5
2020
entrez:
25
6
2019
Statut:
ppublish
Résumé
Phagocytosis, the engulfment of particulate matter, requires the coordinated polymerization of F-actin; however, the nature and dynamics of the F-actin structures generated during the process are incompletely defined. Using super-resolution microscopy, we observed the formation of podosome-like structures during Fc receptor-mediated phagocytosis. Unlike conventional podosomes, these structures are short lived and vectorial, expanding radially from the sites where phagocytic targets are initially engaged. The expanding ring of podosome-like structures requires the localized formation of PtdIns(3,4,5)P
Identifiants
pubmed: 31231039
pii: S1534-5807(19)30426-5
doi: 10.1016/j.devcel.2019.05.028
pii:
doi:
Substances chimiques
Actins
0
Integrins
0
Phosphatidylinositol Phosphates
0
Phosphatidylinositols
0
Receptors, Fc
0
phosphatidylinositol 3,4,5-triphosphate
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
397-410.e3Subventions
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.