Acoustofluidic separation of cells and particles.
Chemistry
Engineering
Nanoscience and technology
Journal
Microsystems & nanoengineering
ISSN: 2055-7434
Titre abrégé: Microsyst Nanoeng
Pays: England
ID NLM: 101695458
Informations de publication
Date de publication:
2019
2019
Historique:
received:
30
10
2018
revised:
12
03
2019
accepted:
14
03
2019
entrez:
25
6
2019
pubmed:
25
6
2019
medline:
25
6
2019
Statut:
epublish
Résumé
Acoustofluidics, the integration of acoustics and microfluidics, is a rapidly growing research field that is addressing challenges in biology, medicine, chemistry, engineering, and physics. In particular, acoustofluidic separation of biological targets from complex fluids has proven to be a powerful tool due to the label-free, biocompatible, and contact-free nature of the technology. By carefully designing and tuning the applied acoustic field, cells and other bioparticles can be isolated with high yield, purity, and biocompatibility. Recent advances in acoustofluidics, such as the development of automated, point-of-care devices for isolating sub-micron bioparticles, address many of the limitations of conventional separation tools. More importantly, advances in the research lab are quickly being adopted to solve clinical problems. In this review article, we discuss working principles of acoustofluidic separation, compare different approaches of acoustofluidic separation, and provide a synopsis of how it is being applied in both traditional applications, such as blood component separation, cell washing, and fluorescence activated cell sorting, as well as emerging applications, including circulating tumor cell and exosome isolation.
Identifiants
pubmed: 31231539
doi: 10.1038/s41378-019-0064-3
pii: 64
pmc: PMC6545324
doi:
Types de publication
Journal Article
Langues
eng
Pagination
32Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM127714
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD086325
Pays : United States
Organisme : NHLBI NIH HHS
ID : R43 HL140800
Pays : United States
Organisme : NIGMS NIH HHS
ID : R44 GM125439
Pays : United States
Déclaration de conflit d'intérêts
Conflict of interestT.J.H. has four US patents (patent numbers: 8,573,060; 9,608,547; 9,606,086; and 9,757,699) related to acoustofluidics and acoustic tweezers. He has also co-founded a start-up company, Ascent Bio-Nano Technologies Inc., to commercialize technologies involving acoustofluidics and acoustic tweezers.
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