The role of ceramide in regulating endoplasmic reticulum function.
Ceramide
Ceramide domains
Ceramide synthase
Endoplasmic reticulum
Membrane fluidity
Sphingolipids
Journal
Biochimica et biophysica acta. Molecular and cell biology of lipids
ISSN: 1879-2618
Titre abrégé: Biochim Biophys Acta Mol Cell Biol Lipids
Pays: Netherlands
ID NLM: 101731727
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
04
04
2019
revised:
15
06
2019
accepted:
18
06
2019
pubmed:
25
6
2019
medline:
14
4
2020
entrez:
25
6
2019
Statut:
ppublish
Résumé
Sphingolipids (SLs) are an important class of membrane lipids containing a long chain sphingoid base backbone. SL synthesis is compartmentalized between two major cell organelles, the endoplasmic reticulum (ER) and the Golgi apparatus. The initial steps of sphingolipid synthesis take place in the ER, where the simplest SL, ceramide, is synthesized. Although ceramide is a critical membrane component, an imbalance of ceramide levels can have significant deleterious effects on cell properties leading to events such as apoptosis. For this reason and others, ER ceramide levels must be tightly regulated. Here, we describe the biological and biophysical properties of ceramide and discuss how this might impact the ER membrane. This article is part of a special issue entitled: ER Platforms for Membrane Lipid Dynamics.
Identifiants
pubmed: 31233888
pii: S1388-1981(19)30118-0
doi: 10.1016/j.bbalip.2019.06.015
pii:
doi:
Substances chimiques
Ceramides
0
Sphingolipids
0
Sphingosine N-Acyltransferase
EC 2.3.1.24
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
158489Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.