Microbiota and Neurodevelopmental Trajectories: Role of Maternal and Early-Life Nutrition.
Brain development
Diet
Early life
Gut-brain axis
Microbiota
Neuropsychiatry
Nutrition
Stress
Journal
Annals of nutrition & metabolism
ISSN: 1421-9697
Titre abrégé: Ann Nutr Metab
Pays: Switzerland
ID NLM: 8105511
Informations de publication
Date de publication:
2019
2019
Historique:
entrez:
25
6
2019
pubmed:
25
6
2019
medline:
25
8
2020
Statut:
ppublish
Résumé
Pregnancy and early life are characterized by marked changes in body microbial composition. Intriguingly, these changes take place simultaneously with neurodevelopmental plasticity, suggesting a complex dialogue between the microbes that inhabit the gastrointestinal tract and the brain. The purpose of this chapter is to describe the natural trajectory of microbiota during pregnancy and early life, as well as review the literature available on its interaction with neurodevelopment. Several lines of evidence show that the gut microbiota interacts with diet, drugs and stress both prenatally and postnatally. Clinical and preclinical studies are illuminating how these disruptions result in different developmental outcomes. Understanding the role of the microbiota in neurodevelopment may lead to novel approaches to the study of the pathophysiology and treatment of neuropsychiatric disorders.
Identifiants
pubmed: 31234188
pii: 000499144
doi: 10.1159/000499144
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
16-27Informations de copyright
© 2019 S. Karger AG, Basel.