Development of Oxidized Polyvinyl Alcohol-Based Nerve Conduits Coupled with the Ciliary Neurotrophic Factor.

bioactive scaffolds chemical oxidation ciliary neurotrophic factor drug delivery functionalization nerve conduits neural regeneration peripheral nerve injury polyvinyl alcohol

Journal

Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929

Informations de publication

Date de publication:
21 Jun 2019
Historique:
received: 26 04 2019
revised: 09 06 2019
accepted: 19 06 2019
entrez: 26 6 2019
pubmed: 27 6 2019
medline: 27 6 2019
Statut: epublish

Résumé

Functionalized synthetic conduits represent a promising strategy to enhance peripheral nerve regeneration by guiding axon growth while delivering therapeutic neurotrophic factors. In this work, hollow nerve conduits made of polyvinyl alcohol partially oxidized with bromine (OxPVA_Br

Identifiants

DOI: 10.3390/ma12121996 PMID: 31234386 PMC: PMC6631399
pubmed: 31234386
pii: ma12121996
doi: 10.3390/ma12121996
pmc: PMC6631399
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : 'Consorzio per la Ricerca Sanitaria' (CORIS) of the Veneto Region, Italy; (L.i.f.e.L.a.b. Program)
ID : DGR1017, July 17, 2018

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Auteurs

Andrea Porzionato (A)

Department of Neurosciences, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, Italy. andrea.porzionato@unipd.it.
L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via N. Giustiniani 2, 35128 Padova, Italy. andrea.porzionato@unipd.it.

Silvia Barbon (S)

Department of Neurosciences, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, Italy. silvia.barbon@unipd.it.
L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via N. Giustiniani 2, 35128 Padova, Italy. silvia.barbon@unipd.it.
ORCID: 0000-0003-2435-0753

Elena Stocco (E)

Department of Neurosciences, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, Italy. elena.stocco@gmail.com.
L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via N. Giustiniani 2, 35128 Padova, Italy. elena.stocco@gmail.com.

Daniele Dalzoppo (D)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35128 Padova, Italy. dalzoppodaniele@gmail.com.

Martina Contran (M)

Department of Neurosciences, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, Italy. martina.contran@gmail.com.
ORCID: 0000-0002-3709-8414

Enrico De Rose (E)

Department of Neurosciences, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, Italy. enrico.derose@studenti.unipd.it.

Pier Paolo Parnigotto (PP)

Foundation for Biology and Regenerative Medicine, Tissue Engineering and Signaling (T.E.S.) Onlus, 35030 Padua, Italy. pierpaolo.parnigotto@unipd.it.

Veronica Macchi (V)

Department of Neurosciences, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, Italy. veronica.macchi@unipd.it.
L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via N. Giustiniani 2, 35128 Padova, Italy. veronica.macchi@unipd.it.

Claudio Grandi (C)

Department of Pharmaceutical and Pharmacological Sciences, University of Padova, Via F. Marzolo 5, 35128 Padova, Italy. claudio.grandi@unipd.it.

Raffaele De Caro (R)

Department of Neurosciences, Section of Human Anatomy, University of Padova, Via A. Gabelli 65, 35121 Padova, Italy. raffaele.decaro@unipd.it.
L.i.f.e.L.a.b. Program, Consorzio per la Ricerca Sanitaria (CORIS), Veneto Region, Via N. Giustiniani 2, 35128 Padova, Italy. raffaele.decaro@unipd.it.

Classifications MeSH