Interrogation of Phenotypic Plasticity between Epithelial and Mesenchymal States in Breast Cancer.
copy number variations (CNV)
epithelial-mesenchymal transition (EMT)
intratumoral heterogeneity
mesenchymal-epithelial transition (MET)
phenotypic plasticity
single cell-derived clones
whole exome sequencing
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
21 Jun 2019
21 Jun 2019
Historique:
received:
28
05
2019
revised:
19
06
2019
accepted:
20
06
2019
entrez:
26
6
2019
pubmed:
27
6
2019
medline:
27
6
2019
Statut:
epublish
Résumé
Dynamic interconversions between transitional epithelial and mesenchymal states underpin the epithelial mesenchymal plasticity (EMP) seen in some carcinoma cell systems. We have delineated epithelial and mesenchymal subpopulations existing within the PMC42-LA breast cancer cell line by their EpCAM expression. These purified but phenotypically plastic states, EpCAM
Identifiants
pubmed: 31234417
pii: jcm8060893
doi: 10.3390/jcm8060893
pmc: PMC6617164
pii:
doi:
Types de publication
Journal Article
Langues
eng
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