The Role of Adipose Tissue in the Pathogenesis and Therapeutic Outcomes of Inflammatory Bowel Disease.
adipose tissue
inflammation
inflammatory bowel disease
mesentery
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
21 06 2019
21 06 2019
Historique:
received:
31
05
2019
revised:
16
06
2019
accepted:
18
06
2019
entrez:
26
6
2019
pubmed:
27
6
2019
medline:
27
6
2019
Statut:
epublish
Résumé
Though historically regarded as an inert energy store, adipose tissue is a complex endocrine organ, which is increasingly implicated in the pathogenesis of inflammatory bowel disease (IBD). Accumulating evidence points to visceral adipose tissue and specifically to its mesenteric component, or "creeping fat" as impacting on the disease course through its immunomodulatory properties. On the one hand, mesenteric fat acts as a physical barrier to inflammation and is involved in controlling host immune response to translocation of gut bacteria. On the other hand, however, there exists a strong link between visceral fat and complicated course of the disease with unfavorable therapeutic outcomes. Furthermore, "creeping fat" appears to play different roles in different IBD phenotypes, with the greatest pathogenetic contribution probably to an ileal form of Crohn's disease. In this review, we summarize and discuss the existing literature on the subject and identify high-priority areas for future research. It may be that a better understanding of the role of mesenteric fat in IBD will determine new therapeutic targets and translate into improved clinical outcomes.
Identifiants
pubmed: 31234447
pii: cells8060628
doi: 10.3390/cells8060628
pmc: PMC6627060
pii:
doi:
Substances chimiques
Adipokines
0
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Références
Physiol Rep. 2015 Aug;3(8):
pubmed: 26265756
Am J Gastroenterol. 2018 Jun;113(6):883-889
pubmed: 29867171
Biochem Biophys Res Commun. 1999 Apr 2;257(1):79-83
pubmed: 10092513
Inflamm Bowel Dis. 2015 Feb;21(2):361-8
pubmed: 25563694
Nat Rev Immunol. 2014 Mar;14(3):141-53
pubmed: 24566914
J Pediatr Gastroenterol Nutr. 2018 Jun;66(6):915-919
pubmed: 29287006
Gastroenterology. 2008 Mar;134(3):688-95
pubmed: 18325386
Endokrynol Pol. 2013;64(3):226-31
pubmed: 23873428
Gastroenterology. 2006 Apr;130(4):1047-53
pubmed: 16618398
Dis Colon Rectum. 2018 Jun;61(6):706-712
pubmed: 29722729
Inflamm Bowel Dis. 2013 Dec;19(13):2949-56
pubmed: 23945182
Obes Facts. 2009;2(6):370-2
pubmed: 20090388
J Biol Chem. 2000 Aug 11;275(32):24255-63
pubmed: 10823826
Abdom Imaging. 2015 Oct;40(7):2210-8
pubmed: 26048698
J Physiol Pharmacol. 2009 Jun;60(2):41-7
pubmed: 19617644
J Med Chem. 2012 May 10;55(9):4027-61
pubmed: 22260081
Gut. 2018 Oct;67(10):1813-1823
pubmed: 28877980
J Eur Acad Dermatol Venereol. 2011 Sep;25(9):1007-11
pubmed: 21492252
Int J Inflam. 2017;2017:7646859
pubmed: 28487813
Dig Dis Sci. 2015 Aug;60(8):2436-45
pubmed: 25799938
Aliment Pharmacol Ther. 2018 Jun;47(11):1472-1479
pubmed: 29665045
J Physiol Pharmacol. 2013 Oct;64(5):587-95
pubmed: 24304573
J Immunol. 2005 May 1;174(9):5789-95
pubmed: 15843582
PLoS One. 2017 May 11;12(5):e0177175
pubmed: 28493988
Metabolism. 2010 Jan;59(1):93-9
pubmed: 19765775
Lancet. 2016 Jan 9;387(10014):156-67
pubmed: 26490195
Gut. 2005 Jun;54(6):789-96
pubmed: 15888786
J Leukoc Biol. 2008 Apr;83(4):804-16
pubmed: 18252866
J Clin Invest. 2002 Oct;110(8):1093-103
pubmed: 12393845
Inflamm Bowel Dis. 2016 Sep;22(9):2206-12
pubmed: 27508511
Clin Transl Gastroenterol. 2016 Oct 27;7(10):e199
pubmed: 27787512
World J Gastroenterol. 2014 Jun 14;20(22):6912-7
pubmed: 24944482
Inflamm Res. 2015 Feb;64(2):85-95
pubmed: 25548799
PPAR Res. 2012;2012:620839
pubmed: 22997506
Br J Surg. 1992 Sep;79(9):955-8
pubmed: 1422768
Proc Natl Acad Sci U S A. 2010 May 11;107(19):8772-7
pubmed: 20421464
Ann Gastroenterol. 2016 Oct-Dec;29(4):424-438
pubmed: 27708507
FASEB J. 2004 Apr;18(6):696-8
pubmed: 14977884
Inflamm Bowel Dis. 2014 Dec;20(12):2286-91
pubmed: 25222655
Gut. 2007 Apr;56(4):577-83
pubmed: 16956921
Inflamm Bowel Dis. 2016 Jun;22(6):1483-95
pubmed: 27167572
J Immunol. 2007 Feb 1;178(3):1748-58
pubmed: 17237424
Int J Obes (Lond). 2008 Aug;32 Suppl 3:S56-9
pubmed: 18695655
Nutrition. 2009 Feb;25(2):172-81
pubmed: 18849144
Inflamm Bowel Dis. 2008 Sep;14(9):1205-13
pubmed: 18425803
FASEB J. 1999 Feb;13(2):305-12
pubmed: 9973318
Gut. 2013 Nov;62(11):1642-52
pubmed: 24104885
Clin Exp Rheumatol. 2008 Mar-Apr;26(2):311-6
pubmed: 18565254
Br J Pharmacol. 2002 Nov;137(6):799-804
pubmed: 12411410
Inflamm Bowel Dis. 2008 Jun;14(6):850-7
pubmed: 18213696
Cell Mol Immunol. 2014 Jul;11(4):355-66
pubmed: 24727542
Mucosal Immunol. 2012 Sep;5(5):580-91
pubmed: 22569302
Nature. 2001 May 31;411(6837):599-603
pubmed: 11385576
Dis Colon Rectum. 1971 Jan-Feb;14(1):17-23
pubmed: 5552686
Clin Exp Immunol. 1995 Dec;102(3):448-55
pubmed: 8536356
Biochem Biophys Res Commun. 2011 May 6;408(2):339-43
pubmed: 21514279
Inflamm Bowel Dis. 2007 Nov;13(11):1357-64
pubmed: 17604368
Gut. 2004 Jul;53(7):965-72
pubmed: 15194645
Inflamm Bowel Dis. 2006 Feb;12(2):100-5
pubmed: 16432373
Dis Markers. 2014;2014:162517
pubmed: 24659847
Inflamm Bowel Dis. 2010 Apr;16(4):630-7
pubmed: 19714754
N Engl J Med. 2009 Nov 19;361(21):2066-78
pubmed: 19923578
Inflamm Bowel Dis. 2009 Dec;15(12):1897-905
pubmed: 19408337
Crit Care. 2011 Apr 20;15(2):221
pubmed: 21586104
Inflamm Bowel Dis. 2012 Aug;18(8):1550-7
pubmed: 22407798
World J Gastroenterol. 2005 Dec 14;11(46):7314-7
pubmed: 16437634
Inflamm Bowel Dis. 2006 Jun;12(6):471-7
pubmed: 16775490
Obesity (Silver Spring). 2009 Apr;17(4):648-56
pubmed: 19148127
Eur J Gastroenterol Hepatol. 2016 Jul;28(7):814-9
pubmed: 26934527
Ann N Y Acad Sci. 2006 Aug;1072:407-9
pubmed: 17057223
Inflamm Bowel Dis. 2015 Nov;21(11):2590-7
pubmed: 26222339
Dermatology. 2017;233(5):378-389
pubmed: 29232663
Can J Gastroenterol. 2005 Sep;19 Suppl A:5A-36A
pubmed: 16151544
J Crohns Colitis. 2010 Feb;4(1):28-62
pubmed: 21122489
Prog Cardiovasc Dis. 2009 Sep-Oct;52(2):126-40
pubmed: 19732605
Dig Dis Sci. 2008 Aug;53(8):2215-21
pubmed: 18080768
Obes Rev. 2010 Jan;11(1):11-8
pubmed: 19656312
Clin Gastroenterol Hepatol. 2011 Aug;9(8):684-687.e1
pubmed: 21642015
Inflamm Bowel Dis. 2008 Nov;14(11):1555-61
pubmed: 18521926
Endocrinology. 2010 Jan;151(1):56-62
pubmed: 19966187
Obesity (Silver Spring). 2007 May;15(5):1172-8
pubmed: 17495193
Nat Microbiol. 2017 Feb 13;2:17004
pubmed: 28191884
Nat Rev Gastroenterol Hepatol. 2015 Dec;12(12):720-7
pubmed: 26323879
Aliment Pharmacol Ther. 2017 May;45(9):1255-1264
pubmed: 28244124
World J Gastroenterol. 2016 Sep 21;22(35):7868-81
pubmed: 27672284
Am J Gastroenterol. 2013 Apr;108(4):575-82
pubmed: 23318483
JAMA. 1984 Jan 6;251(1):73-9
pubmed: 6361290
Endocrinology. 2007 Oct;148(10):4687-94
pubmed: 17640997
Autoimmun Rev. 2014 Sep;13(9):981-1000
pubmed: 25092612
J Biol Chem. 1995 Nov 10;270(45):26746-9
pubmed: 7592907
Gut. 2013 Jun;62(6):852-62
pubmed: 22543156
J Crohns Colitis. 2013 Aug;7(7):e241-8
pubmed: 23040290
N Engl J Med. 2010 Aug 26;363(9):803-6
pubmed: 20660395
Int J Obes (Lond). 2016 May;40(5):883-6
pubmed: 26841729
Science. 2012 Jun 8;336(6086):1268-73
pubmed: 22674334
Inflamm Bowel Dis. 2016 Feb;22(2):279-92
pubmed: 26535766
J Physiol Pharmacol. 2012 Oct;63(5):471-81
pubmed: 23211301
Gut. 2012 Jan;61(1):86-94
pubmed: 21930728
J Immunol. 2008 Sep 1;181(5):3620-7
pubmed: 18714036
J Biol Chem. 2004 Mar 26;279(13):12152-62
pubmed: 14699128
J Res Med Sci. 2017 Feb 16;22:28
pubmed: 28413425
Scand J Immunol. 2011 Nov;74(5):463-70
pubmed: 21671974
Life Sci. 2014 Jul 25;109(1):20-9
pubmed: 24931905
Inflamm Bowel Dis. 2014 Sep;20(9):1568-74
pubmed: 24983977
Dig Surg. 2014;31(3):219-24
pubmed: 25277149
Am J Pathol. 2007 Jun;170(6):1931-41
pubmed: 17525261
J Immunol. 2005 Jul 1;175(1):487-93
pubmed: 15972683
Gastroenterol Clin Biol. 2003 Nov;27(11):987-91
pubmed: 14732844
Pediatr Res. 2013 Oct;74(4):420-6
pubmed: 23823177
Science. 2005 Jan 21;307(5708):426-30
pubmed: 15604363
Z Rheumatol. 2017 Nov;76(9):789-797
pubmed: 27515182
Immunology. 2009 Feb;126(2):233-45
pubmed: 18624726
Gut. 2017 Sep;66(9):1573-1583
pubmed: 27216938
Trends Endocrinol Metab. 2014 Jun;25(6):293-302
pubmed: 24793638
Hippokratia. 2012 Oct;16(4):360-5
pubmed: 23935318
J Crohns Colitis. 2019 Jan 1;13(1):79-91
pubmed: 30272118
J Pediatr Gastroenterol Nutr. 2017 Dec;65(6):633-638
pubmed: 28362691
Clin Transl Gastroenterol. 2010 Oct 21;1:e1
pubmed: 23238652
Nat Genet. 1996 Sep;14(1):95-7
pubmed: 8782827
J Leukoc Biol. 2002 Aug;72(2):330-8
pubmed: 12149424
Curr Opin Gastroenterol. 2014 Nov;30(6):559-65
pubmed: 25188546
Colorectal Dis. 2016 Feb;18(2):163-72
pubmed: 26391914
Clin Gastroenterol Hepatol. 2013 Nov;11(11):1453-1459.e4
pubmed: 23639598
PLoS One. 2013 Oct 24;8(10):e78495
pubmed: 24205244
Free Radic Res. 2003 Aug;37(8):809-14
pubmed: 14567439
Eur J Gastroenterol Hepatol. 2007 Sep;19(9):789-94
pubmed: 17700265
Gastroenterology. 2012 Jan;142(1):46-54.e42; quiz e30
pubmed: 22001864
Gastroenterology. 1994 Sep;107(3):643-9
pubmed: 8076751
Gut. 2006 Mar;55(3):432-3
pubmed: 16474110
Inflamm Bowel Dis. 2017 Jan;23(1):82-88
pubmed: 27893544
Pharmacol Ther. 2015 Jul;151:16-31
pubmed: 25709099
Lancet. 2018 Dec 23;390(10114):2769-2778
pubmed: 29050646
Clin Exp Immunol. 2012 Dec;170(3):358-64
pubmed: 23121676
J Crohns Colitis. 2019 Jan 1;13(1):58-66
pubmed: 30239655
J Clin Endocrinol Metab. 2005 Jun;90(6):3510-6
pubmed: 15784704
Diabetes Metab. 2012 Dec;38(6):538-43
pubmed: 23182460
Hum Mol Genet. 2005 May 15;14(10):1245-50
pubmed: 15790594
Clin Exp Dermatol. 2018 Jul;43(5):536-545
pubmed: 29356069
Front Genet. 2015 Jun 23;6:219
pubmed: 26157455
Ann Gastroenterol. 2011;24(1):20-28
pubmed: 24714276
J Investig Med. 2009 Oct;57(7):784-8
pubmed: 19730134
J Biol Chem. 2003 Mar 14;278(11):9850-5
pubmed: 12519759
Mol Biol Cell. 2004 May;15(5):2484-91
pubmed: 15034137
Med Sci Monit. 2017 May 29;23:2599-2606
pubmed: 28552901
Nature. 1998 Aug 27;394(6696):897-901
pubmed: 9732873