Differential effects of delivery hospital on mortality and morbidity in minority premature and low birth weight neonates.
Black or African American
Hispanic or Latino
Humans
Infant
Infant Mortality
/ ethnology
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases
/ ethnology
Insurance, Health
Intensive Care Units, Neonatal
/ classification
Minority Groups
Retrospective Studies
Tertiary Care Centers
United States
/ epidemiology
White People
Journal
Journal of perinatology : official journal of the California Perinatal Association
ISSN: 1476-5543
Titre abrégé: J Perinatol
Pays: United States
ID NLM: 8501884
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
received:
05
12
2018
accepted:
22
05
2019
revised:
08
05
2019
pubmed:
27
6
2019
medline:
29
9
2020
entrez:
26
6
2019
Statut:
ppublish
Résumé
To describe variation in mortality and morbidity effects of high-level, high-volume delivery hospital between racial/ethnic groups and insurance groups. Retrospective cohort including infants born at 24-32 weeks gestation or birth weights ≤2500 g in California, Missouri, and Pennsylvania between 1995 and 2009 (n = 636,764). Multivariable logistic random-effects models determined differential effects of birth hospital level/volume on mortality and morbidity through an interaction term between delivery hospital level/volume and either maternal race or insurance status. Compared to non-Hispanic white neonates, odds of complications of prematurity were 14-25% lower for minority infants in all gestational age and birth weight cohorts delivering at high-level, high-volume centers (odds ratio (ORs) 0.75-0.86, p < 0.001-0.005). Effect size was greatest for Hispanic infants. No difference was noted by insurance status. Neonates of minority racial/ethnic status derive greater morbidity benefits than non-Hispanic white neonates from delivery at hospitals with high-level, high-volume neonatal intensive care units.
Identifiants
pubmed: 31235781
doi: 10.1038/s41372-019-0423-9
pii: 10.1038/s41372-019-0423-9
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
404-411Subventions
Organisme : NICHD NIH HHS
ID : R01 HD084819
Pays : United States
Références
Martin JA, Hamilton BE, Osterman MJK, Driscoll AK, Drake P. Births: final data for 2016. Natl Vital Stat Rep. 2018;67:1–54.
pubmed: 30707672
Lau C, Ambalavanan N, Chakraborty H, Wingate MS, Carlo WA. Extremely low birth weight and infant mortality rates in the United States. Pediatrics. 2013;131:855–60. https://doi.org/10.1542/peds.2012-2471 .
doi: 10.1542/peds.2012-2471
pubmed: 23545381
Institute of Medicine. Preterm birth: causes, consequences, and prevention. Washington, DC: The National Academic Press; 2007.
Yu VYH, Doyle LW. Regionalized long-term follow-up. Semin Neonatol. 2004;9:135–44. https://doi.org/10.1016/j.siny.2003.08.008 .
doi: 10.1016/j.siny.2003.08.008
pubmed: 16256717
Phibbs CS, Baker LC, Caughey AB, Danielsen B, Schmitt SK, Phibbs RH. Level and volume of neonatal intensive care and mortality in very-low-birth-weight infants. N Engl J Med. 2007;356:2165–75. https://doi.org/10.1056/NEJMsa065029 .
doi: 10.1056/NEJMsa065029
pubmed: 17522400
Cifuentes J, Bronstein J, Phibbs CS, Phibbs RH, Schmitt SK, Carlo WA. Mortality in low birth weight infants according to level of neonatal care at hospital of birth. Pediatrics. 2002;109:745–51.
doi: 10.1542/peds.109.5.745
pubmed: 11986431
Lasswell SM, Barfield WD, Rochat RW, Blackmon L. Perinatal regionalization for very low-birth-weight and very preterm infants: a meta-analysis. JAMA. 2010;304:992–1000. https://doi.org/10.1001/jama.2010.1226 .
doi: 10.1001/jama.2010.1226
Chung JH, Phibbs CS, Boscardin WJ, Kominski GF, Ortega AN, Needleman J. The effect of neonatal intensive care level and hospital volume on mortality of very low birth weight infants. Med Care. 2010;48:635–44. https://doi.org/10.1097/MLR.0b013e3181dbe887 .
doi: 10.1097/MLR.0b013e3181dbe887
pubmed: 20548252
Lorch SA, Baiocchi M, Ahlberg CE, Small DS. The differential impact of delivery hospital on the outcomes of premature infants. Pediatrics. 2012;130:270–8. https://doi.org/10.1542/peds.2011-2820 .
doi: 10.1542/peds.2011-2820
pubmed: 22778301
pmcid: 4074612
Markus AR, Krohe S, Garro N, Gerstein M, Pellegrini C. Examining the association between Medicaid coverage and preterm births using 2010–2013 National Vital Statistics Birth Data. J Child Poverty. 2016;23:79–94. https://doi.org/10.1080/10796126.2016.1254601 .
doi: 10.1080/10796126.2016.1254601
Durbin DR, Giardino AP, Shaw KN, Harris MC, Silber JH. The effect of insurance status on likelihood of neonatal interhospital transfer. Pediatrics. 1997;100:E8.
doi: 10.1542/peds.100.3.e8
pubmed: 9271623
Howell EA, Janevic T, Herbert PL, Egorova NN, Balbierz A, Zeitlin J. Differences in morbidity and mortality rates in black, white, and hispanic very preterm infants among New York City hospitals. JAMA Pediatr. 2018;172:269–77. https://doi.org/10.1001/jamapediatrics.2017.4402 .
doi: 10.1001/jamapediatrics.2017.4402
pubmed: 29297054
pmcid: 5796743
Horbar JD, Edwards EM, Greenberg LT, Profit J, Draper D, Helkey D, et al. Racial segregation and inequality in the neonatal intensive care unit for very low-birth-weight and very preterm infants. JAMA Pediatr. 2019. https://doi.org/10.1001/jamapediatrics.2019.0241 .
doi: 10.1001/jamapediatrics.2019.0241
pubmed: 30907924
pmcid: 6503514
Howell EA, Hebert PL, Zeitlin J. Racial segregation and inequality of care in neonatal intensive care units is unacceptable. JAMA Pediatr. 2019. https://doi.org/10.1001/jamapediatrics.2019.0240 .
doi: 10.1001/jamapediatrics.2019.0240
pubmed: 30907946
American Academy of Pediatrics Committee on Fetus and Newborn. Levels of neonatal care. Pediatrics. 2012;130:587–97. https://doi.org/10.1542/peds.2012-199 .
doi: 10.1542/peds.2012-199
Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Neonatal outcomes of extremely pretern infants from the NICHD Neonatal Research Network. Pediatrics. 2010;126:443–56. https://doi.org/10.1542/peds.2009-2959 .
doi: 10.1542/peds.2009-2959
pubmed: 20732945
pmcid: 2982806
Schmidt B, Asztalos EV, Roberts RS, Robertson CM, Sauve RS, Whitfield MF, et al. Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months. JAMA. 2003;289:1124–9. https://doi.org/10.1001/jama.289.9.1124 .
doi: 10.1001/jama.289.9.1124
pubmed: 12622582
Ananth C, Basso O. Impact of pregnancy-induced hypertension on stillbirth and neonatal mortality in first and higher order births: a population-based study. Epidemiology. 2010;21:118–23. https://doi.org/10.1097/EDE.0b013e3181c297af .
doi: 10.1097/EDE.0b013e3181c297af
pubmed: 20010214
pmcid: 2841017
Perger L, Mukhopadhyay D, Komidar L, Wiggins-Dohlvik K, Uddin MN, Beeram M. Maternal pre-eclampsia as a risk factor for necrotizing enterocolitis. J Matern-Fetal Neonatal Med. 2016;29:2098–103. https://doi.org/10.3109/14767058.2015.1076386 .
doi: 10.3109/14767058.2015.1076386
pubmed: 27480208
Leary P, Leary SE, Stout K, Schwartz S, Easterling TR. Maternal, perinatal, and postnatal outcomes in women with chronic heart disease in Washington State. Obstet Gynecol. 2012;120:1283–90. https://doi.org/10.1097/AOG.0b013e3182733d56 .
doi: 10.1097/AOG.0b013e3182733d56
pubmed: 23168751
pmcid: 4113683
Kendrick J, Sharma S, Holmen J, Palit S, Nuccio E, Chonchol M. Kidney disease and maternal and fetal outcomes in pregnancy. Am J Kidney Dis. 2015;66:55–59. https://doi.org/10.1053/j.ajkd.2014.11.019 .
doi: 10.1053/j.ajkd.2014.11.019
pubmed: 25600490
pmcid: 4485539
Nevis I, Reitsma, Dominic A, McDonald S, Thabane L, Aki E, et al. Pregnancy outcomes in women with chronic kidney disease: a systematic review. Clin J Am Soc Nephrol. 2011;6:2587–98. https://doi.org/10.2215/CJN.10841210 .
doi: 10.2215/CJN.10841210
pubmed: 21940842
pmcid: 3359575
Persson M, Shah PS, Rusconi F, Reichman B, Modi N, Kusuda S, et al. Association of maternal diabetes with neonatal outcomes of very preterm and very low-birth-weight infants: an International Cohort Study. JAMA Pediatr. 2018;172:867–75. https://doi.org/10.1001/jamapediatrics.2018.1811 .
doi: 10.1001/jamapediatrics.2018.1811
pubmed: 29971428
pmcid: 6143059
Grandi C, Tapia JL, Cardoso VC. Impact of maternal diabetes mellitus on mortality and morbidity of very low birth weight infants: a multicenter Latin America study. J Pediatr. 2015;91:234–41. https://doi.org/10.1016/j.jped.2014.08.007 .
doi: 10.1016/j.jped.2014.08.007
Shapiro-Mendoza C, Tomashek K, Kotelchuck M, Barfield W, Nannini JW, Declercq E. Effect of late-preterm birth and maternal medical conditions on newborn morbidity risk. Pediatrics. 2008;121:e223–32. https://doi.org/10.1542/peds.2006-3629 .
doi: 10.1542/peds.2006-3629
pubmed: 18245397
Yee W, Soraisham A, Shah V, Aziz K, Yoon W, Lee SK. Incidence and timing of presentation of necrotizing enterocolitis in preterm infants. Pediatrics. 2012;129:e298–304. https://doi.org/10.1542/peds.2011-2022 .
doi: 10.1542/peds.2011-2022
pubmed: 22271701
Samuels N, van de Graaf R, de Jonge R, Reiss IK, Vermeulen M. Risk factors for necrotizing enterocolitis in neonates: a systematic review of prognostic studies. BMC Pediatr. 2017;17:105 https://doi.org/10.1186/s12887-017-0847-3 .
doi: 10.1186/s12887-017-0847-3
pubmed: 28410573
pmcid: 5391569
Cotten CM, Taylor S, Stoll B, Goldberg RN, Hansen NI, Sanchez PJ, et al. Prolonged duration of initial empirical antibiotic treatment is associated with increased rates of necrotizing enterocolitis and death for extremely low birth weight infants. Pediatrics. 2009;123:58–66. https://doi.org/10.1542/peds.2007-3423 .
doi: 10.1542/peds.2007-3423
pubmed: 19117861
pmcid: 2760222
Fang JL, Sorita A, Carey WA, Colby CE, Murad MH, Alahdab F, et al. Interventions to prevent retinopathy of prematurity: a meta-analysis. Pediatrics. 2016;137 https://doi.org/10.1542/peds.2015-3387 .
doi: 10.1542/peds.2015-3387
pubmed: 26962240
Trembath A, Laughon M. Predictors of bronchopulmonary dysplasia. Clin Perinatol. 2012;39:585–601. https://doi.org/10.1016/j.clp.2012.06.014 .
doi: 10.1016/j.clp.2012.06.014
pubmed: 22954271
pmcid: 3443959
Roberts D, Brown J, Medley N, Dalziel SR. Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth. Cochrane Database Syst Rev. 2017;3. https://doi.org/10.1002/14651858.CD004454.pub2 .
Linder N, Haskin O, Levit O, Klinger G, Prince T, Naor N, et al. Risk factors for intraventricular hemorrhage in very low birth weight premature infants: a retrospective case–control study. Pediatrics. 2003;111(5 Part 1):e590–5.
doi: 10.1542/peds.111.5.e590
pubmed: 12728115
Chevallier M, Debillon T, Pierrat V, Delorme P, Kayem G, Durox M, et al. Leading causes of preterm delivery as risk factors for intraventricular hemorrhage in very preterm infants: results of the EPIPAGE 2 cohort study. Am J Obstet Gynecol. 2017;216:518.el–518.e12. https://doi.org/10.1016/j.ajog.2017.01.002 .
doi: 10.1016/j.ajog.2017.01.002
Handley SC, Passarella M, Lee HC, Lorch SA. Incidence trends and risk factor variation in severe intraventricular hemorrhage across a population based cohort. J Pediatr. 2018;200:24–29.e3. https://doi.org/10.1016/j.jpeds.2018.04.020 .
doi: 10.1016/j.jpeds.2018.04.020
pubmed: 29754865
pmcid: 6109595
Profit J, Gould J, Bennett M, Goldstein BA, Draper D, Phibbs C, et al. Racial/ethnic disparity in NICU quality of care delivery. Pediatrics. 2017;140. https://doi.org/10.1542/peds.2017-0918 .
doi: 10.1542/peds.2017-0918
pubmed: 28847984
pmcid: 5574732
Jha AK, Orav EJ, Epstein AM. Low-quality, high-cost hospitals, mainly in South, care for sharply higher shares of elderly black, Hispanic, and Medicaid patients. Health Aff. 2011;30:1904–11. https://doi.org/10.1377/hlthaff.2011.0027 .
doi: 10.1377/hlthaff.2011.0027
Comstock R, Castillo E, Lindsay S. Four-year review of the use of race and ethnicity in epidemiologic and public health research. Am J Epidemiol. 2004;159:611–9.
doi: 10.1093/aje/kwh084
pubmed: 15003966
Burchard EG, Ziv E, Coyle N, Gomez SL, Tang H, Karter AJ. The importance of race and ethnic background in biomedical research and clinical practice. N Engl J Med. 2003;348:1170–5. https://doi.org/10.1056/NEJMsb025007 .
doi: 10.1056/NEJMsb025007
pubmed: 12646676
Baker LC, Afendulis CC, McConville S, Phibbs CS, Fuentes-Afflick E. Differences in neonatal motality among whites and Asian American subgroups: evidence from California. Arch Pediatr Adolesc Med. 2007;161:69–76. https://doi.org/10.1001/archpedi.161.1.69 .
doi: 10.1001/archpedi.161.1.69
pubmed: 17199070
pmcid: 2376811
Rice WS, Goldfarb SS, Brisendine AE, Burrows S, Wingate MS. Disparities in infant mortality by race among Hispanic and non-Hispanic infants. Matern Child Health J. 2017;21:1581–8. https://doi.org/10.1007/s10995-017-2290-3 .
doi: 10.1007/s10995-017-2290-3
pubmed: 28197819
pmcid: 5498242