The apelinergic system: a perspective on challenges and opportunities in cardiovascular and metabolic disorders.
Apela/Toddler/Elabela
apelin
apelin receptor/APLNR/APJ
cardiovascular protection
heart failure
hypertension
preeclampsia
pulmonary arterial hypertension
septic shock
type 2 diabetes
water retention/hyponatremic disorders
Journal
Annals of the New York Academy of Sciences
ISSN: 1749-6632
Titre abrégé: Ann N Y Acad Sci
Pays: United States
ID NLM: 7506858
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
30
01
2019
revised:
11
04
2019
accepted:
02
05
2019
pubmed:
27
6
2019
medline:
6
5
2020
entrez:
26
6
2019
Statut:
ppublish
Résumé
The apelinergic pathway has been generating increasing interest in the past few years for its potential as a therapeutic target in several conditions associated with the cardiovascular and metabolic systems. Indeed, preclinical and, more recently, clinical evidence both point to this G protein-coupled receptor as a target of interest in the treatment of not only cardiovascular disorders such as heart failure, pulmonary arterial hypertension, atherosclerosis, or septic shock, but also of additional conditions such as water retention/hyponatremic disorders, type 2 diabetes, and preeclampsia. While it is a peculiar system with its two classes of endogenous ligand, the apelins and Elabela, its intricacies are a matter of continuing investigation to finely pinpoint its potential and how it enables crosstalk between the vasculature and organ systems of interest. In this perspective article, we first review the current knowledge on the role of the apelinergic pathway in the above systems, as well as the associated therapeutic indications and existing pharmacological tools. We also offer a perspective on the challenges and potential ahead to advance the apelinergic system as a target for therapeutic intervention in several key areas.
Identifiants
pubmed: 31236974
doi: 10.1111/nyas.14123
pmc: PMC6834863
mid: NIHMS1027768
doi:
Substances chimiques
Apelin
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
12-33Subventions
Organisme : CIHR
Pays : Canada
Organisme : NHLBI NIH HHS
ID : R01 HL142818
Pays : United States
Organisme : American Heart Association
Pays : International
Organisme : Institut National de la Santé et de la Recherche Médicale
Pays : International
Organisme : NHLBI NIH HHS
ID : R56 HL136715
Pays : United States
Organisme : Fonds de Recherche du Québec - Santé
Pays : International
Organisme : Heart and Stroke Foundation of Canada
Pays : International
Organisme : Agence Nationale de la Recherche
Pays : International
Organisme : NIH HHS
Pays : United States
Informations de copyright
© 2019 New York Academy of Sciences.
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