High immune cytolytic activity in tumor-free tongue tissue confers better prognosis in patients with squamous cell carcinoma of the oral tongue.
cytolytic activity
oral tongue
prognosis
squamous cell carcinoma
Journal
The journal of pathology. Clinical research
ISSN: 2056-4538
Titre abrégé: J Pathol Clin Res
Pays: England
ID NLM: 101658534
Informations de publication
Date de publication:
10 2019
10 2019
Historique:
received:
08
01
2019
revised:
18
06
2019
accepted:
19
06
2019
pubmed:
27
6
2019
medline:
24
7
2020
entrez:
26
6
2019
Statut:
ppublish
Résumé
Immune cells and cytolytic activity within the tumor microenvironment are being intensively studied. Through transcriptome profiling, immune cell enumeration using the xCell tool and cytolytic activity quantification according to granzyme A (GZMA) and perforin (PRF1) mRNA levels, we investigated immunoreactivity in tumor and/or tumor-free tongue tissue samples from 31 patients with squamous cell carcinoma of the oral tongue and 14 healthy individuals (control tongue tissues). We found significantly altered immune cell compositions (p < 0.001) and elevated cytolytic activity (p < 0.001) in tumor compared to tumor-free samples, and altered infiltration of a subset of immune cells (e.g. CD8
Identifiants
pubmed: 31237113
doi: 10.1002/cjp2.138
pmc: PMC6817829
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
240-247Informations de copyright
© 2019 The Authors. The Journal of Pathology: Clinical Research published by The Pathological Society of Great Britain and Ireland and John Wiley & Sons Ltd.
Références
Ann Surg Oncol. 2018 Aug;25(8):2323-2331
pubmed: 29770915
PLoS One. 2017 Sep 19;12(9):e0184201
pubmed: 28926591
Semin Cancer Biol. 2018 Oct;52(Pt 2):228-240
pubmed: 29355614
Nature. 2015 Jan 29;517(7536):576-82
pubmed: 25631445
Lancet. 2018 May 26;391(10135):2128-2139
pubmed: 29754777
J Clin Invest. 2014 Apr;124(4):1446-53
pubmed: 24691479
Cell. 2015 Jan 15;160(1-2):48-61
pubmed: 25594174
Cancer Immunol Immunother. 2018 Jul;67(7):1031-1040
pubmed: 29541787
Nat Med. 2015 Aug;21(8):938-945
pubmed: 26193342
Mod Pathol. 2015 Jan;28(1):14-29
pubmed: 24925058
Nat Rev Cancer. 2018 May;18(5):269-282
pubmed: 29497144
Nat Rev Cancer. 2011 Jan;11(1):9-22
pubmed: 21160525
BMC Cancer. 2011 Oct 11;11:437
pubmed: 21989116
Nucleic Acids Res. 2010 Dec;38(22):e204
pubmed: 20929874
Nat Rev Immunol. 2015 Jun;15(6):388-400
pubmed: 25998963
Br J Cancer. 2015 Jul 14;113(2):321-6
pubmed: 26057450
Nat Med. 2018 May;24(5):541-550
pubmed: 29686425
Annu Rev Immunol. 2016 May 20;34:539-73
pubmed: 26927206
Immunity. 2018 Apr 17;48(4):812-830.e14
pubmed: 29628290
Cancer. 1953 Sep;6(5):963-8
pubmed: 13094644
Sci Rep. 2016 Aug 30;6:32579
pubmed: 27572959
J Pathol. 2014 Jan;232(2):199-209
pubmed: 24122236
J Oral Pathol Med. 2012 May;41(5):379-83
pubmed: 22084865
Nat Rev Cancer. 2018 Jan;18(1):19-32
pubmed: 29217838
Cell Rep. 2017 Jan 3;18(1):248-262
pubmed: 28052254
J Carcinog. 2012;11:18
pubmed: 23230394
Nat Commun. 2017 Oct 20;8(1):1077
pubmed: 29057876
Nat Rev Genet. 2016 Jul 4;17(8):441-58
pubmed: 27376489
Clin Cancer Res. 2015 Nov 15;21(22):5047-56
pubmed: 26567364
Oncotarget. 2017 Mar 21;8(12):19389-19402
pubmed: 28038473
PLoS One. 2012;7(9):e46575
pubmed: 23029552
CA Cancer J Clin. 2018 Nov;68(6):394-424
pubmed: 30207593
Genome Biol. 2017 Nov 15;18(1):220
pubmed: 29141660