Mechanistic Insights into the Role of Atg11 in Selective Autophagy.
Atg11
Atg17
autophagosome
membrane tethering
scaffold protein
Journal
Journal of molecular biology
ISSN: 1089-8638
Titre abrégé: J Mol Biol
Pays: Netherlands
ID NLM: 2985088R
Informations de publication
Date de publication:
03 01 2020
03 01 2020
Historique:
received:
25
04
2019
revised:
11
06
2019
accepted:
13
06
2019
pubmed:
27
6
2019
medline:
25
6
2020
entrez:
26
6
2019
Statut:
ppublish
Résumé
Macroautophagy (referred to hereafter as autophagy) is an intracellular degradation pathway in which the formation of a double-membrane vesicle called the autophagosome is a key event in the transport of multiple cytoplasmic cargo (e.g., proteins, protein aggregates, lipid droplets or organelles) to the vacuole (lysosome in mammals) for degradation and recycling. During this process, autophagosomes are formed de novo by membrane fusion events leading to phagophore formation initiated at the phagophore assembly site. In yeast, Atg11 and Atg17 function as protein scaffolds, essential for selective and non-selective types of autophagy, respectively. While Atg17 functions in non-selective autophagy are well-defined in the literature, less attention is concentrated on recent findings regarding the roles of Atg11 in selective autophagy. Here, we summarize current knowledge about the Atg11 scaffold protein and review recent findings in the context of its role in selective autophagy initiation and autophagosome formation.
Identifiants
pubmed: 31238043
pii: S0022-2836(19)30402-4
doi: 10.1016/j.jmb.2019.06.017
pmc: PMC6925662
mid: NIHMS1534139
pii:
doi:
Substances chimiques
Atg11 protein, S cerevisiae
0
Atg17 protein, S cerevisiae
0
Autophagy-Related Proteins
0
Saccharomyces cerevisiae Proteins
0
Vesicular Transport Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
104-122Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK041737
Pays : United States
Organisme : NIAID NIH HHS
ID : R03 AI142388
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.
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