Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer.
Animals
Carrier Proteins
/ genetics
Cell Line, Tumor
Disease-Free Survival
Female
Gene Expression Regulation, Neoplastic
Humans
Lung Neoplasms
/ secondary
Mice, Nude
Microfilament Proteins
/ genetics
NF-kappa B
/ metabolism
Phosphotransferases (Alcohol Group Acceptor)
/ genetics
Signal Transduction
Triple Negative Breast Neoplasms
/ genetics
Xenograft Model Antitumor Assays
Journal
Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R
Informations de publication
Date de publication:
15 08 2019
15 08 2019
Historique:
received:
03
12
2018
revised:
16
04
2019
accepted:
19
06
2019
pubmed:
27
6
2019
medline:
17
6
2020
entrez:
27
6
2019
Statut:
ppublish
Résumé
Triple-negative breast cancer (TNBC) is the most aggressive breast cancer subtype. To identify TNBC therapeutic targets, we performed integrative bioinformatics analysis of multiple breast cancer patient-derived gene expression datasets and focused on kinases with FDA-approved or in-pipeline inhibitors. Sphingosine kinase 1 (SPHK1) was identified as a top candidate. SPHK1 overexpression or downregulation in human TNBC cell lines increased or decreased spontaneous metastasis to lungs in nude mice, respectively. SPHK1 promoted metastasis by transcriptionally upregulating the expression of the metastasis-promoting gene
Identifiants
pubmed: 31239273
pii: 0008-5472.CAN-18-3803
doi: 10.1158/0008-5472.CAN-18-3803
pmc: PMC6697620
mid: NIHMS1532907
doi:
Substances chimiques
Carrier Proteins
0
FSCN1 protein, human
0
Microfilament Proteins
0
NF-kappa B
0
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
sphingosine kinase
EC 2.7.1.-
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4211-4226Subventions
Organisme : NCI NIH HHS
ID : P30 CA016672
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA112567
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA184836
Pays : United States
Informations de copyright
©2019 American Association for Cancer Research.
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