Molecular markers relevant to myocardial injury following dental extraction in patients with or without coronary artery disease.
Periodontitis
Special care dentistry
Journal
BDJ open
ISSN: 2056-807X
Titre abrégé: BDJ Open
Pays: England
ID NLM: 101709456
Informations de publication
Date de publication:
2019
2019
Historique:
received:
16
12
2018
revised:
07
05
2019
accepted:
12
05
2019
entrez:
27
6
2019
pubmed:
27
6
2019
medline:
27
6
2019
Statut:
epublish
Résumé
The aim of this study was to characterize biological changes following dental extractions in patients with or without coronary artery disease (CAD). Forty-five patients (36 males and 9 females) referred for dental extraction underwent treatment and provided blood samples before, immediately after, and 24 h after the procedure. A broad array of biomarkers was employed to assess myocardial injury (highly sensitive troponin T, hs-TnT), bacterial burden (LPS endotoxin activity), and systemic inflammation (CRP, fibrinogen, IFN-γ, IL-1β, IL-6, IL-8, IL-10, IL-12, and TNF-α). Dental extraction in patients with or without CAD was associated with rises in hs-TnT ( Simple dental extractions may cause mild increase in hs-TnT, indicating minor myocardial injury in both patients with or without CAD. Acute systemic inflammation and endotoxemia could represent a possible link between invasive dental treatment and increased risk of acute cardiovascular events. These findings indicate that invasive dental treatment (as simple as a single dental extraction) may impact negatively on clinical outcomes in dental patients, especially those with CAD.
Identifiants
pubmed: 31240112
doi: 10.1038/s41405-019-0018-8
pii: 18
pmc: PMC6586777
doi:
Types de publication
Journal Article
Langues
eng
Pagination
9Déclaration de conflit d'intérêts
Competing interestsThe authors declare no competing interests.
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