Corticosteroids and Regional Variations in Thickness of the Human Cerebral Cortex across the Lifespan.
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
21 03 2020
21 03 2020
Historique:
received:
05
02
2019
revised:
29
04
2019
accepted:
01
05
2019
pubmed:
27
6
2019
medline:
16
6
2021
entrez:
27
6
2019
Statut:
ppublish
Résumé
Exposures to life stressors accumulate across the lifespan, with possible impact on brain health. Little is known, however, about the mechanisms mediating age-related changes in brain structure. We use a lifespan sample of participants (n = 21 251; 4-97 years) to investigate the relationship between the thickness of cerebral cortex and the expression of the glucocorticoid- and the mineralocorticoid-receptor genes (NR3C1 and NR3C2, respectively), obtained from the Allen Human Brain Atlas. In all participants, cortical thickness correlated negatively with the expression of both NR3C1 and NR3C2 across 34 cortical regions. The magnitude of this correlation varied across the lifespan. From childhood through early adulthood, the profile similarity (between NR3C1/NR3C2 expression and thickness) increased with age. Conversely, both profile similarities decreased with age in late life. These variations do not reflect age-related changes in NR3C1 and NR3C2 expression, as observed in 5 databases of gene expression in the human cerebral cortex (502 donors). Based on the co-expression of NR3C1 (and NR3C2) with genes specific to neural cell types, we determine the potential involvement of microglia, astrocytes, and CA1 pyramidal cells in mediating the relationship between corticosteroid exposure and cortical thickness. Therefore, corticosteroids may influence brain structure to a variable degree throughout life.
Identifiants
pubmed: 31240317
pii: 5521088
doi: 10.1093/cercor/bhz108
pmc: PMC7444740
doi:
Substances chimiques
NR3C1 protein, human
0
NR3C2 protein, human
0
Receptors, Glucocorticoid
0
Receptors, Mineralocorticoid
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
575-586Subventions
Organisme : NIA NIH HHS
ID : P30 AG066444
Pays : United States
Organisme : NIMH NIH HHS
ID : U54 MH091657
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS017950
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG054076
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG059421
Pays : United States
Organisme : Medical Research Council
ID : MR/R024065/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : P01 AG026276
Pays : United States
Organisme : Medical Research Council
ID : MR/M013111/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG043434
Pays : United States
Organisme : NIBIB NIH HHS
ID : R01 EB009352
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000448
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG052409
Pays : United States
Organisme : NIA NIH HHS
ID : P01 AG003991
Pays : United States
Organisme : NIA NIH HHS
ID : P50 AG005681
Pays : United States
Organisme : Medical Research Council
ID : G1001245
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N027558/1
Pays : United Kingdom
Organisme : NCATS NIH HHS
ID : UL1 TR002345
Pays : United States
Organisme : Medical Research Council
ID : G0701120
Pays : United Kingdom
Informations de copyright
© The Author(s) 2019. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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