The association of preoperative reduced glomerular filtration rate with higher staging and histology grades in patients with urinary tract cancers.
Glomerular filtration rate
Histology
Recurrence
Staging
Urinary tract cancers
Journal
International urology and nephrology
ISSN: 1573-2584
Titre abrégé: Int Urol Nephrol
Pays: Netherlands
ID NLM: 0262521
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
22
02
2019
accepted:
18
06
2019
pubmed:
27
6
2019
medline:
28
2
2020
entrez:
27
6
2019
Statut:
ppublish
Résumé
Studies have shown the increased incidence of urinary tract cancers which are associated with a decrease in glomerular filtration rate (GFR). We hypothesized that patients with GFR < 60 ml/min/1.73 m Retrospective clinical data and pathology reports were completed for 2116 patients. Patients were divided into two subgroups regarding GFR; the first group with GFR < 60 ml/min/1.73 m We have found significantly higher number of cancers with higher histology grades and higher staging in group of patients with GFR < 60 ml/min/1.73 m Higher staging and histology grades in patients with urinary tract cancers are associated with reduced GFR. Reduced GFR in these patients is a risk factor for cancer recurrence and cancer-related survival. Possible involvement of uremic toxins must be taken into account especially when cancers are predominantly located in estrogen sensitive organs. These patients should be intensively monitored and probably be more aggressively treated.
Identifiants
pubmed: 31240530
doi: 10.1007/s11255-019-02216-z
pii: 10.1007/s11255-019-02216-z
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1537-1544Références
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