Bio-Inspired Dual-Selective
Antineoplastic Agents
/ chemistry
Biological Products
/ chemistry
DNA-Binding Proteins
/ antagonists & inhibitors
Drug Design
G-Quadruplexes
HCT116 Cells
Humans
Imidazoles
/ chemistry
Jurkat Cells
MCF-7 Cells
Molecular Docking Simulation
/ methods
Protein Binding
/ physiology
Proto-Oncogene Proteins c-bcl-2
/ antagonists & inhibitors
Purines
/ chemistry
Transcription Factors
/ antagonists & inhibitors
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
12 03 2020
12 03 2020
Historique:
pubmed:
27
6
2019
medline:
20
8
2020
entrez:
27
6
2019
Statut:
ppublish
Résumé
In the search for new drug-like selective G-quadruplex binders, a bioinspired design focused on the use of nucleobases as synthons in a multicomponent reaction was herein proved to be viable and successful. Hence, a new class of multifunctionalized imidazo[2,1-
Identifiants
pubmed: 31241946
doi: 10.1021/acs.jmedchem.9b00262
doi:
Substances chimiques
Antineoplastic Agents
0
BCL2 protein, human
0
Biological Products
0
DNA-Binding Proteins
0
Imidazoles
0
MYCBP protein, human
0
Proto-Oncogene Proteins c-bcl-2
0
Purines
0
Transcription Factors
0
imidazole
7GBN705NH1
purine
W60KTZ3IZY
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM