Non-invasively triggered spreading depolarizations induce a rapid pro-inflammatory response in cerebral cortex.
Cortical spreading depolarization
NSAIDs
dexamethasone
inflammation
optogenetics
Journal
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
ISSN: 1559-7016
Titre abrégé: J Cereb Blood Flow Metab
Pays: United States
ID NLM: 8112566
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
pubmed:
27
6
2019
medline:
15
12
2020
entrez:
27
6
2019
Statut:
ppublish
Résumé
Cortical spreading depolarization (CSD) induces pro-inflammatory gene expression in brain tissue. However, previous studies assessing the relationship between CSD and inflammation have used invasive methods that directly trigger inflammation. To eliminate the injury confounder, we induced CSDs non-invasively through intact skull using optogenetics in Thy1-channelrhodopsin-2 transgenic mice. We corroborated our findings by minimally invasive KCl-induced CSDs through thinned skull. Six CSDs induced over 1 h dramatically increased cortical
Identifiants
pubmed: 31242047
doi: 10.1177/0271678X19859381
pmc: PMC7181092
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1117-1131Subventions
Organisme : NINDS NIH HHS
ID : K08 NS112601
Pays : United States
Organisme : NCATS NIH HHS
ID : KL2 TR002542
Pays : United States
Organisme : NINDS NIH HHS
ID : R25 NS065743
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG051506
Pays : United States
Organisme : NINDS NIH HHS
ID : P01 NS055104
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102969
Pays : United States
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