Pannexins in Acute Kidney Injury.
ATP
Acute kidney injury
Adenosine
Mitochondria
Pannexins
Purinergic signaling
Journal
Nephron
ISSN: 2235-3186
Titre abrégé: Nephron
Pays: Switzerland
ID NLM: 0331777
Informations de publication
Date de publication:
2019
2019
Historique:
received:
25
03
2019
accepted:
03
06
2019
pubmed:
27
6
2019
medline:
2
7
2020
entrez:
27
6
2019
Statut:
ppublish
Résumé
Acute kidney injury (AKI) is highly prevalent among hospitalized patients and is associated with serious consequences with limited pharmacological treatment options. Pannexin 1 (Panx1) channel is a ubiquitously expressed nonselective membrane transport channel that efficiently effluxes ATP and plays a central role in the progression of inflammatory diseases. Animal models that target Panx1 through pharmacological inhibition or genetic deficiency have better outcomes in minimizing inflammation and associated pathology. Given the involvement of Panx1 at multiple steps of -inflammatory pathology, Panx1 could be a potential therapeutic target in the treatment of AKI. Further research is needed in elaborating the mechanisms and identifying Panx1-specific inhibitor molecules to better understand the role of Panx1 in AKI pathology arising due to diverse insults.
Identifiants
pubmed: 31242494
pii: 000501278
doi: 10.1159/000501278
pmc: PMC6821569
mid: NIHMS1037807
doi:
Substances chimiques
Connexins
0
Nerve Tissue Proteins
0
PANX1 protein, human
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
158-161Subventions
Organisme : NIDDK NIH HHS
ID : P30 DK079337
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK062324
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK123248
Pays : United States
Organisme : NIDDK NIH HHS
ID : T32 DK072922
Pays : United States
Informations de copyright
© 2019 S. Karger AG, Basel.
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