Metal Nanoparticles Released from Dental Implant Surfaces: Potential Contribution to Chronic Inflammation and Peri-Implant Bone Loss.
osteolysis
reactive oxygen species
titanium nanoparticles
Journal
Materials (Basel, Switzerland)
ISSN: 1996-1944
Titre abrégé: Materials (Basel)
Pays: Switzerland
ID NLM: 101555929
Informations de publication
Date de publication:
25 Jun 2019
25 Jun 2019
Historique:
received:
29
05
2019
revised:
18
06
2019
accepted:
20
06
2019
entrez:
28
6
2019
pubmed:
28
6
2019
medline:
28
6
2019
Statut:
epublish
Résumé
Peri-implantitis is an inflammatory disease affecting tissues surrounding dental implants. Although it represents a common complication of dental implant treatments, the underlying mechanisms have not yet been fully described. The aim of this study is to identify the role of titanium nanoparticles released form the implants on the chronic inflammation and bone lysis in the surrounding tissue. We analyzed the in vitro effect of titanium (Ti) particle exposure on mesenchymal stem cells (MSCs) and fibroblasts (FU), evaluating cell proliferation by MTT test and the generation of reactive oxygen species (ROS). Subsequently, in vivo analysis of peri-implant Ti particle distribution, histological, and molecular analyses were performed. Ti particles led to a time-dependent decrease in cell viability and increase in ROS production in both MSCs and FU. Tissue analyses revealed presence of oxidative stress, high extracellular and intracellular Ti levels and imbalanced bone turnover. High expression of ZFP467 and the presence of adipose-like tissue suggested dysregulation of the MSC population; alterations in vessel morphology were identified. The results suggest that Ti particles may induce the production of high ROS levels, recruiting abnormal quantity of neutrophils able to produce high level of metalloproteinase. This induces the degradation of collagen fibers. These events may influence MSC commitment, with an imbalance of bone regeneration.
Identifiants
pubmed: 31242601
pii: ma12122036
doi: 10.3390/ma12122036
pmc: PMC6630980
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Proc Natl Acad Sci U S A. 2000 Aug 1;97(16):8841-8
pubmed: 10922044
J Cell Biochem. 2000 Sep 14;79(4):532-41
pubmed: 10996844
J Bone Miner Res. 2001 Apr;16(4):660-70
pubmed: 11315993
J Bone Miner Res. 2001 Jun;16(6):1004-14
pubmed: 11393777
Int J Oral Maxillofac Implants. 2001 May-Jun;16(3):389-93
pubmed: 11432658
Semin Hematol. 2001 Jul;38(3):276-85
pubmed: 11486316
J Bone Miner Res. 2001 Nov;16(11):2082-91
pubmed: 11697805
Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9656-61
pubmed: 12118119
Arterioscler Thromb Vasc Biol. 2003 Jun 1;23(6):953-64
pubmed: 12689916
Spine (Phila Pa 1976). 2003 Oct 15;28(20):S125-38
pubmed: 14560184
Dev Cell. 2004 Apr;6(4):483-95
pubmed: 15068789
Physiol Rev. 2004 Jul;84(3):869-901
pubmed: 15269339
Int J Obes (Lond). 2005 Apr;29(4):398-405
pubmed: 15672109
Nat Immunol. 2005 Nov;6(11):1133-41
pubmed: 16200068
Immunity. 2006 Jan;24(1):79-91
pubmed: 16413925
Biotechnol Prog. 2007 Jan-Feb;23(1):210-6
pubmed: 17269690
J Orthop Res. 2007 May;25(5):603-11
pubmed: 17278141
Cell. 2007 Aug 10;130(3):456-69
pubmed: 17693256
J Periodontal Res. 2007 Oct;42(5):402-9
pubmed: 17760817
Mol Endocrinol. 1991 Dec;5(12):1806-14
pubmed: 1791831
J Cell Biochem. 2007 Dec 15;102(6):1375-88
pubmed: 17975795
J Immunol. 2007 Nov 15;179(10):6933-42
pubmed: 17982084
J Orthop Sci. 2007 Nov;12(6):568-77
pubmed: 18040640
Int J Biochem Cell Biol. 2008;40(6-7):1334-47
pubmed: 18083622
Proc Natl Acad Sci U S A. 2008 Jan 29;105(4):1226-31
pubmed: 18212116
Nat Immunol. 2008 Aug;9(8):866-72
pubmed: 18604212
Nature. 2008 Jul 24;454(7203):428-35
pubmed: 18650913
Injury. 2008 Sep;39 Suppl 2:S45-57
pubmed: 18804573
Nat Rev Rheumatol. 2009 Jul;5(7):365-72
pubmed: 19468288
Biomaterials. 2010 Mar;31(8):1996-2000
pubmed: 20004468
J Leukoc Biol. 2010 Jan;87(1):93-106
pubmed: 20052802
J Orthop Res. 2010 Jul;28(7):893-9
pubmed: 20058267
Inflamm Res. 2010 Dec;59(12):1091-7
pubmed: 20607583
Arch Dermatol Res. 2011 Jan;303(1):41-7
pubmed: 21046127
J Biol Chem. 2011 Feb 11;286(6):4186-98
pubmed: 21123171
Eur J Med Res. 2010 Nov 4;15 Suppl 2:88-91
pubmed: 21147629
J Clin Periodontol. 2011 Mar;38(3):285-92
pubmed: 21158898
Cytokine. 2011 May;54(2):200-4
pubmed: 21371905
Cell Metab. 2011 Apr 6;13(4):361-366
pubmed: 21459321
Stem Cells Dev. 2012 Mar 20;21(5):767-77
pubmed: 21521013
Med Oral Patol Oral Cir Bucal. 2011 Nov 01;16(7):e937-43
pubmed: 21743412
Clin Dev Immunol. 2012;2012:252460
pubmed: 21808651
J Dent Res. 2012 Jan;91(1):71-7
pubmed: 21979132
J Orthop Res. 2012 Jun;30(6):853-63
pubmed: 22083964
Rheumatol Int. 2013 Mar;33(3):697-703
pubmed: 22531887
Int J Mol Med. 2012 Sep;30(3):502-8
pubmed: 22692760
Int J Oral Sci. 2012 Jun;4(2):64-8
pubmed: 22722639
Clin Oral Implants Res. 2012 Oct;23 Suppl 6:63-5
pubmed: 23062128
Adv Healthc Mater. 2013 Apr;2(4):568-75
pubmed: 23184642
PLoS Pathog. 2012;8(11):e1003047
pubmed: 23209417
PLoS One. 2012;7(11):e49146
pubmed: 23209565
Mol Med. 2013 Apr 30;19:36-42
pubmed: 23508571
J Periodontol. 2013 Apr;84(4):436-43
pubmed: 23537178
Periodontol 2000. 2013 Jun;62(1):256-70
pubmed: 23574471
Minerva Stomatol. 2013 Apr;62(4 Suppl 1):1-7
pubmed: 23756839
PLoS One. 2013 Jul 03;8(7):e66391
pubmed: 23843954
Int J Dent. 2013;2013:312747
pubmed: 24101927
JAMA. 2013 Nov 27;310(20):2191-4
pubmed: 24141714
PLoS One. 2013 Nov 13;8(11):e78903
pubmed: 24236066
Acta Biomater. 2014 Jun;10(6):2379-403
pubmed: 24565531
Nat Commun. 2014 Feb 26;5:3368
pubmed: 24569594
Sci Rep. 2014 Mar 27;4:4493
pubmed: 24670389
J Periodontol. 2014 Nov;85(11):1566-74
pubmed: 24878328
Mediators Inflamm. 2014;2014:185150
pubmed: 24891761
Cell Rep. 2014 Jul 24;8(2):570-82
pubmed: 25043180
J Dent Res. 2015 Feb;94(2):354-61
pubmed: 25406169
J Immunol. 2015 Feb 15;194(4):1763-75
pubmed: 25609842
Int J Mol Cell Med. 2014 Fall;3(4):225-36
pubmed: 25635249
Biochem Biophys Res Commun. 2015 Jun 26;462(2):159-64
pubmed: 25951977
Mater Sci Eng C Mater Biol Appl. 2015;52:225-34
pubmed: 25953562
PLoS One. 2015 May 26;10(5):e0127493
pubmed: 26011447
Food Chem Toxicol. 2015 Nov;85:78-83
pubmed: 26051351
Blood. 2015 Dec 17;126(25):2724-33
pubmed: 26443623
Blood. 2015 Dec 24;126(26):2842-51
pubmed: 26491069
Adv Med. 2014;2014:487903
pubmed: 26556414
Biomaterials. 2016 Feb;80:1-10
pubmed: 26695376
PLoS Pathog. 2015 Dec 31;11(12):e1005347
pubmed: 26720604
J Clin Invest. 2016 Feb;126(2):509-26
pubmed: 26731472
Open Dent J. 2015 Dec 11;9:393-5
pubmed: 26966463
Mini Rev Med Chem. 2016;16(9):762-9
pubmed: 26996620
Acta Biomater. 2017 Jan 15;48:479-488
pubmed: 27838465
Front Endocrinol (Lausanne). 2017 Jan 19;8:5
pubmed: 28154552
Infect Immun. 1987 Oct;55(10):2398-403
pubmed: 2820882
Immunity. 2017 Mar 21;46(3):421-432
pubmed: 28314592
J Periodontal Res. 2017 Dec;52(6):946-954
pubmed: 28612506
Nanotoxicology. 2017 Aug;11(6):737-750
pubmed: 28669258
J Periodontal Res. 2018 Feb;53(1):1-11
pubmed: 28766712
J Dent. 2017 Nov;66:91-101
pubmed: 28800964
J Dent Res. 2018 Mar;97(3):259-265
pubmed: 29130804
Sci Rep. 2018 Mar 23;8(1):5108
pubmed: 29572540
J Biol Chem. 1996 Jan 12;271(2):603-6
pubmed: 8557658
Epidemiology. 1997 Nov;8(6):609-11
pubmed: 9345656
J Periodontal Res. 1998 Nov;33(8):491-9
pubmed: 9879523