Subunit Vaccine Approaches for African Swine Fever Virus.

ASFV African swine fever virus antibody dependent enhancement antigens disease enhancement immunogens protective immunity subunit vaccines vaccines

Journal

Vaccines
ISSN: 2076-393X
Titre abrégé: Vaccines (Basel)
Pays: Switzerland
ID NLM: 101629355

Informations de publication

Date de publication:
25 Jun 2019
Historique:
received: 19 05 2019
revised: 21 06 2019
accepted: 21 06 2019
entrez: 28 6 2019
pubmed: 28 6 2019
medline: 28 6 2019
Statut: epublish

Résumé

African swine fever virus (ASFV) is the cause of a highly fatal disease in swine, for which there is no available vaccine. The disease is highly contagious and poses a serious threat to the swine industry worldwide. Since its introduction to the Caucasus region in 2007, a highly virulent, genotype II strain of ASFV has continued to circulate and spread into Eastern Europe and Russia, and most recently into Western Europe, China, and various countries of Southeast Asia. This review summarizes various ASFV vaccine strategies that have been investigated, with focus on antigen-, DNA-, and virus vector-based vaccines. Known ASFV antigens and the determinants of protection against ASFV versus immunopathological enhancement of infection and disease are also discussed.

Identifiants

pubmed: 31242632
pii: vaccines7020056
doi: 10.3390/vaccines7020056
pmc: PMC6631172
pii:
doi:

Types de publication

Journal Article Review

Langues

eng

Subventions

Organisme : U.S. Department of Homeland Security
ID : DHS-2010-ST-061-AG0001
Organisme : State of Kansas National Bio and Agro-Defense Facility transition funds
ID : NA

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Auteurs

Natasha N Gaudreault (NN)

Department of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, K224 Mosier Hall, 1800 Denison Ave, Manhattan, KS 66506, USA. nng5757@vet.k-state.edu.

Juergen A Richt (JA)

Department of Diagnostic Medicine & Pathobiology, College of Veterinary Medicine, Kansas State University, K224 Mosier Hall, 1800 Denison Ave, Manhattan, KS 66506, USA. jricht@vet.k-state.edu.

Classifications MeSH