Exo-miRNAs as a New Tool for Liquid Biopsy in Lung Cancer.
exosomes
lung cancer
microRNA
Journal
Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829
Informations de publication
Date de publication:
25 Jun 2019
25 Jun 2019
Historique:
received:
10
05
2019
revised:
19
06
2019
accepted:
24
06
2019
entrez:
28
6
2019
pubmed:
28
6
2019
medline:
28
6
2019
Statut:
epublish
Résumé
Lung cancer is the predominant cause of cancer-related deaths. The high mortality rates are mainly due to the lack of diagnosis before the cancer is at a late stage. Liquid biopsy is a promising technique that could allow early diagnosis of lung cancer and better treatment selection for patients. Cell-free microRNAs have been detected in biological fluids, such as serum and plasma, and are considered interesting biomarkers for lung cancer screening and detection. Exosomes are nanovesicles of 30-150 nm and can be released by different cell types within the tumor microenvironment. Their exosomal composition reflects that of their parental cells and could be potentially useful as a biomarker for lung cancer diagnosis. This review summarizes the state-of-the-art of circulating microRNAs (miRNAs) in lung cancer, focusing on their potential use in clinical practice. Moreover, we describe the importance of exosomal miRNA cargo in lung cancer detection and their potential role during lung carcinogenesis. Finally, we discuss our experience with the analysis of circulating exosomal miRNAs in the bioMILD screening trial.
Identifiants
pubmed: 31242686
pii: cancers11060888
doi: 10.3390/cancers11060888
pmc: PMC6627875
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : U01 CA166905
Pays : United States
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 12162
Organisme : Associazione Italiana per la Ricerca sul Cancro
ID : 14318 and 18812
Organisme : Fondazione Cariplo
ID : 2015-0901
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