Radiosensitization and a Less Aggressive Phenotype of Human Malignant Glioma Cells Expressing Isocitrate Dehydrogenase 1 (IDH1) Mutant Protein: Dissecting the Mechanisms.

IDH1 IDH1R132H atomic force microscopy cell stiffness glioblastoma glioma isocitrate dehydrogenase 1

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
25 Jun 2019
Historique:
received: 29 03 2019
revised: 09 06 2019
accepted: 11 06 2019
entrez: 28 6 2019
pubmed: 28 6 2019
medline: 28 6 2019
Statut: epublish

Résumé

The presence of an isocitrate dehydrogenase 1 (IDH1) mutation is associated with a less aggressive phenotype, increased sensitivity to radiation, and increased overall survival in patients with diffuse glioma. Based on in vitro experimentations in malignant glioma cell lines, the consequences on cellular processes of IDH1

Identifiants

pubmed: 31242696
pii: cancers11060889
doi: 10.3390/cancers11060889
pmc: PMC6627228
pii:
doi:

Types de publication

Journal Article

Langues

eng

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Auteurs

Jacqueline Kessler (J)

Department of Radiotherapy, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097 Halle (Saale), Germany. jacqueline.kessler@uk-halle.de.

Tim Hohmann (T)

Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Große Steinstraße 52, 06108 Halle (Saale), Germany. tim.hohmann@medizin.uni-halle.de.

Antje Güttler (A)

Department of Radiotherapy, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097 Halle (Saale), Germany. antje.guettler@uk-halle.de.

Marina Petrenko (M)

Department of Radiotherapy, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097 Halle (Saale), Germany. marina.petrenko@uk-halle.de.

Christian Ostheimer (C)

Department of Radiotherapy, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097 Halle (Saale), Germany. christian.ostheimer@uk-halle.de.

Urszula Hohmann (U)

Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Große Steinstraße 52, 06108 Halle (Saale), Germany. urszula.grabiec@medizin.uni-halle.de.

Matthias Bache (M)

Department of Radiotherapy, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097 Halle (Saale), Germany. matthias.bache@uk-halle.de.

Faramarz Dehghani (F)

Department of Anatomy and Cell Biology, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Große Steinstraße 52, 06108 Halle (Saale), Germany. faramarz.dehghani@medizin.uni-halle.de.

Dirk Vordermark (D)

Department of Radiotherapy, Faculty of Medicine, Martin Luther University Halle-Wittenberg, Ernst-Grube-Str. 40, 06097 Halle (Saale), Germany. dirk.vordermark@uk-halle.de.

Classifications MeSH