Assessing the relationship between near-infrared spectroscopy-derived regional cerebral oxygenation and neurological dysfunction in critically ill adults: a prospective observational multicentre protocol, on behalf of the Canadian Critical Care Trials Group.

Survivors of critical illness frequently exhibit acute and chronic neurological complications. The underlying aetiology of this dysfunction remains unknown but may be associated with cerebral ischaemia. This study will use near-infrared spectroscopy to non-invasively quantify regional cerebral oxygenation (rSO This multicentre prospective observational study will consider adult patients (≥18 years old) eligible for enrolment if within 24 hours of ICU admission, they require mechanical ventilation and/or vasopressor support. For 72 hours, rSO The study protocol has been approved in Ontario by a central research ethics board (Clinical Trials Ontario); non-Ontario sites will obtain local ethics approval. The study will be conducted under the guidance of the Canadian Critical Care Trials Group (CCCTG) and the results of this study will be presented at national meetings of the CCCTG for internal peer review. Results will also be presented at national/international scientific conferences. On completion, the study findings will be submitted for publication in peer-reviewed journals. NCT03141619.

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© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

Déclaration de conflit d'intérêts

Competing interests: JM is the scientific director of the Canadian Frailty Network. SHS is the cofounder of BKIN Technologies, the manufacturer of the KINARM device. IB receives a stipend from the Trillium Gift of Life Network to support his role as a Regional Medical Lead. NO received funding from the Academic Medical Organization of Southwestern Ontario. MS receives a stipend from the Trillium Gift of Life Network to support his role as a Hospital Donation Physician. DG is funded through a Health-Professional Investigator Award from the Michael Smith Foundation for Health Research. JGB receives a stipend from the Trillium Gift of Life Network to support his role as a Regional Medical Lead.