Conformational transitions of a neurotensin receptor 1-G
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
19
02
2019
accepted:
31
05
2019
pubmed:
28
6
2019
medline:
27
11
2019
entrez:
28
6
2019
Statut:
ppublish
Résumé
Neurotensin receptor 1 (NTSR1) is a G-protein-coupled receptor (GPCR) that engages multiple subtypes of G protein, and is involved in the regulation of blood pressure, body temperature, weight and the response to pain. Here we present structures of human NTSR1 in complex with the agonist JMV449 and the heterotrimeric G
Identifiants
pubmed: 31243364
doi: 10.1038/s41586-019-1337-6
pii: 10.1038/s41586-019-1337-6
pmc: PMC7065593
mid: NIHMS1530687
doi:
Substances chimiques
Oligopeptides
0
Receptors, Neurotensin
0
neurotensin type 1 receptor
0
JMV 449
139026-66-7
GTP-Binding Protein alpha Subunits, Gi-Go
EC 3.6.5.1
Types de publication
Comparative Study
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
80-85Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM083118
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS028471
Pays : United States
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