Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.

Adaptor Proteins, Signal Transducing / genetics Animals Cancellous Bone / cytology Homeostasis Mice Mice, Knockout Osteoblasts / cytology Osteoclasts / cytology RANK Ligand / genetics Receptor Activator of Nuclear Factor-kappa B / genetics
Bif-1 apoptosis autophagy bone remodeling

Journal

Journal of cellular biochemistry
ISSN: 1097-4644
Titre abrégé: J Cell Biochem
Pays: United States
ID NLM: 8205768

Informations de publication

Date de publication:
11 2019
Historique:
received: 05 03 2019
accepted: 31 05 2019
pubmed: 28 6 2019
medline: 9 9 2020
entrez: 28 6 2019
Statut: ppublish

Résumé

Skeletal tissue homeostasis is maintained via the balance of osteoclastic bone resorption and osteoblastic bone formation. Autophagy and apoptosis are essential for the maintenance of homeostasis and normal development in cells and tissues. We found that Bax-interacting factor 1 (Bif-1/Endophillin B1/SH3GLB1), involving in autophagy and apoptosis, was upregulated during osteoclastogenesis. Furthermore, mature osteoclasts expressed Bif-1 in the cytosol, particularly the perinuclear regions and podosome, suggesting that Bif-1 regulates osteoclastic bone resorption. Bif-1-deficient (Bif-1

Identifiants

DOI: 10.1002/jcb.29193 PMID: 31243813
pubmed: 31243813
doi: 10.1002/jcb.29193
doi:

Substances chimiques

Adaptor Proteins, Signal Transducing 0
RANK Ligand 0
Receptor Activator of Nuclear Factor-kappa B 0
Sh3glb1 protein, mouse 0
Tnfrsf11a protein, mouse 0
Tnfsf11 protein, mouse 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

18793-18804

Informations de copyright

© 2019 Wiley Periodicals, Inc.

Auteurs

Kenya Touyama (K)

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.
Division of Developmental Stomatognathic Function Science, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Masud Khan (M)

Department of Basic Oral Health Engineering, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Kazuhiro Aoki (K)

Department of Basic Oral Health Engineering, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Miho Matsuda (M)

Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Fumitaka Hiura (F)

Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Nana Takakura (N)

Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Takuma Matsubara (T)

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.

Yui Harada (Y)

R&D Laboratory for Innovative Biotherapeutics Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Yuna Hirohashi (Y)

Department of Basic Oral Health Engineering, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Yukihiko Tamura (Y)

Section of Pharmacology, Department of Bio-Matrix, Graduate School of Medical and Dental Science, Tokyo Medical and Dental University, Tokyo, Japan.

Jing Gao (J)

Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Kayo Mori (K)

Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Shoichiro Kokabu (S)

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.

Hisataka Yasuda (H)

Nagahama Institute for Biochemical Science, Oriental Yeast Co, Ltd, Shiga, Japan.

Yuko Fujita (Y)

Division of Developmental Stomatognathic Function Science, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.

Koji Watanabe (K)

Division of Developmental Stomatognathic Function Science, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.

Yoshinori Takahashi (Y)

Department of Pediatrics, Penn State College of Medicine, Hershey, Pennsylvania.

Kenshi Maki (K)

Division of Developmental Stomatognathic Function Science, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.

Eijiro Jimi (E)

Division of Molecular Signaling and Biochemistry, Department of Health Improvement, Kyushu Dental University, Kitakyushu, Japan.
Laboratory of Molecular and Cellular Biochemistry, Faculty of Dental Science, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.
Oral Health/Brain Health/Total Health Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
ORCID: 0000-0003-3616-5299

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protéines adaptatrices de la transduction du signal › Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.
questionsmedicales.fr › Eucaryotes › Animaux › Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › Os spongieux › Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.
questionsmedicales.fr › Phénomènes physiologiques › Homéostasie › Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Souris knockout › Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Ostéoblastes › Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.
questionsmedicales.fr › Cellules › Cellules myéloïdes › Ostéoclastes › Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › Facteurs de nécrose tumorale › Ligand de RANK › Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs immunologiques › Récepteurs aux cytokines › Récepteurs aux facteurs de nécrose tumorale › Récepteur activateur du facteur nucléaire Kappa B › Bif-1/Endophilin B1/SH3GLB1 regulates bone homeostasis.