Imaging fibrosis in inflammatory diseases: targeting the exposed extracellular matrix.
Animals
Arthritis, Rheumatoid
/ complications
Copper Radioisotopes
/ metabolism
Dermatitis
/ complications
Disease Models, Animal
Encephalomyelitis, Autoimmune, Experimental
/ complications
Extracellular Matrix
/ metabolism
Fibrosis
/ diagnostic imaging
Glycoproteins
/ genetics
Heterocyclic Compounds, 1-Ring
/ metabolism
Immunoglobulin Fc Fragments
/ genetics
Mice, Inbred C57BL
Pneumonia
/ complications
Positron-Emission Tomography
/ methods
Sensitivity and Specificity
Staining and Labeling
/ methods
fibrosis
glycoprotein VI
positron emission tomography
Journal
Theranostics
ISSN: 1838-7640
Titre abrégé: Theranostics
Pays: Australia
ID NLM: 101552395
Informations de publication
Date de publication:
2019
2019
Historique:
received:
31
07
2018
accepted:
10
12
2018
entrez:
28
6
2019
pubmed:
28
6
2019
medline:
19
6
2020
Statut:
epublish
Résumé
In a variety of diseases, from benign to life-threatening ones, inflammation plays a major role. Monitoring the intensity and extent of a multifaceted inflammatory process has become a cornerstone in diagnostics and therapy monitoring. However, the current tools lack the ability to provide insight into one of its most crucial aspects, namely, the alteration of the extracellular matrix (ECM). Using a radiolabeled platelet glycoprotein VI-based ECM-targeting fusion protein (GPVI-Fc), we investigated how binding of GPVI-Fc on fibrous tissue could uncover the progression of several inflammatory disease models at different stages (rheumatoid arthritis, cutaneous delayed-type hypersensitivity, lung inflammation and experimental autoimmune encephalomyelitis).
Identifiants
pubmed: 31244929
doi: 10.7150/thno.28892
pii: thnov09p2868
pmc: PMC6568181
doi:
Substances chimiques
Copper Radioisotopes
0
Glycoproteins
0
Heterocyclic Compounds, 1-Ring
0
Immunoglobulin Fc Fragments
0
Revacept
0
1,4,7-triazacyclononane-N,N',N''-triacetic acid
56491-86-2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2868-2881Déclaration de conflit d'intérêts
Competing interests: M. Gawaz is a shareholder of advanceCOR GmbH.
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