cell therapy
cord blood
endothelial cells
endothelial progenitor cell
ex vivo expansion
Journal
Future science OA
ISSN: 2056-5623
Titre abrégé: Future Sci OA
Pays: England
ID NLM: 101665030
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
23
08
2018
accepted:
09
01
2019
entrez:
28
6
2019
pubmed:
28
6
2019
medline:
28
6
2019
Statut:
epublish
Résumé
Endothelial cells (ECs), isolated from peripheral blood (PB), bone marrow (BM) and cord blood (CB), are limited in numbers and expansion has had limited success. We used a novel serum-free medium (EndoGo) to evaluate effects on Flow cytometry and matrigel were used to determine expansion of ECs and for determination of the EC progenitor cell. EndoGo™-containing cultures demonstrated superior expansion and stimulated proliferation of two distinct subpopulations, CD34 These findings demonstrate the potential of EndoGo to expand CB ECs, which could generate increased numbers of ECs for therapeutic applications.
Identifiants
pubmed: 31245040
doi: 10.2144/fsoa-2018-0103
pmc: PMC6554691
doi:
Types de publication
Journal Article
Langues
eng
Pagination
FSO376Déclaration de conflit d'intérêts
Financial & competing interests disclosure A Ogunye, IK McNiece and J Kellner have no conflict of interest and do not have affiliation with Biological Industries. S Daniliuc, M Genser-Nir, Y-Y Miropolski and D Fiorentini are employees of Biological Industries and supplied EndoGo for experimentation. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.
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