Low S-adenosylmethionine/ S-adenosylhomocysteine Ratio in Urine is Associated with Chronic Kidney Disease.
S-adenosylhomocysteine
S-adenosylmethionine
chronic kidney disease
homocysteine
hyperhomocysteinemia
urine
Journal
Laboratory medicine
ISSN: 1943-7730
Titre abrégé: Lab Med
Pays: England
ID NLM: 0250641
Informations de publication
Date de publication:
02 Jan 2020
02 Jan 2020
Historique:
pubmed:
28
6
2019
medline:
4
6
2020
entrez:
28
6
2019
Statut:
ppublish
Résumé
To evaluate the association of S-adenosylmethionine (SAM) and S-adenosylhomocysteine (SAH) in urine with chronic kidney disease (CKD). Case-control study including 50 patients with CKD and 20 healthy volunteers. SAM level and SAM/SAH ratio in urine were significantly lower in patients than in control individuals (P <.001 and P = .01, respectively). The estimated glomerular filtration rate was associated with the SAM level (P = .04) and the SAM/SAH ratio in urine (P = .01). CKD is associated not only with the decline in the SAM level but also with the decrease in the SAM/SAH ratio in urine. Thus, use of the urinary SAM/SAH ratio as a noninvasive diagnostic indicator of renal function seems promising.
Identifiants
pubmed: 31247080
pii: 5524278
doi: 10.1093/labmed/lmz035
doi:
Substances chimiques
Biomarkers
0
S-Adenosylmethionine
7LP2MPO46S
S-Adenosylhomocysteine
979-92-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
80-85Informations de copyright
© American Society for Clinical Pathology 2019. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.