Visual Cortical Plasticity in Retinitis Pigmentosa.
Adult
Dominance, Ocular
/ physiology
Electroretinography
Female
Humans
Male
Middle Aged
Neuronal Plasticity
/ physiology
Prospective Studies
Retinitis Pigmentosa
/ physiopathology
Vision Disparity
/ physiology
Vision, Binocular
/ physiology
Visual Acuity
/ physiology
Visual Cortex
/ physiology
Visual Fields
/ physiology
Journal
Investigative ophthalmology & visual science
ISSN: 1552-5783
Titre abrégé: Invest Ophthalmol Vis Sci
Pays: United States
ID NLM: 7703701
Informations de publication
Date de publication:
03 06 2019
03 06 2019
Historique:
entrez:
28
6
2019
pubmed:
28
6
2019
medline:
18
12
2019
Statut:
ppublish
Résumé
Retinitis pigmentosa is a family of genetic diseases inducing progressive photoreceptor degeneration. There is no cure for retinitis pigmentosa, but prospective therapeutic strategies are aimed at restoring or substituting retinal input. Yet, it is unclear whether the visual cortex of retinitis pigmentosa patients retains plasticity to react to the restored visual input. To investigate short-term visual cortical plasticity in retinitis pigmentosa, we tested the effect of short-term (2 hours) monocular deprivation on sensory ocular dominance (measured with binocular rivalry) in a group of 14 patients diagnosed with retinitis pigmentosa with a central visual field sparing greater than 20° in diameter. After deprivation most patients showed a perceptual shift in ocular dominance in favor of the deprived eye (P < 0.001), as did control subjects, indicating a level of visual cortical plasticity in the normal range. The deprivation effect correlated negatively with visual acuity (r = -0.63, P = 0.015), and with the amplitude of the central 18° focal electroretinogram (r = -0.68, P = 0.015) of the deprived eye, revealing that in retinitis pigmentosa stronger visual impairment is associated with higher plasticity. Our results provide a new tool to assess the ability of retinitis pigmentosa patients to adapt to altered visual inputs, and suggest that in retinitis pigmentosa the adult brain has sufficient short-term plasticity to benefit from prospective therapies.
Identifiants
pubmed: 31247082
pii: 2737425
doi: 10.1167/iovs.18-25750
pmc: PMC6746622
mid: EMS84361
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
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