Brown Spider (
Analgesics
/ pharmacology
Animals
Anti-Inflammatory Agents
/ pharmacology
Antineoplastic Agents
/ pharmacology
Humans
Immunotherapy
Insecticides
/ pharmacology
Neuroprotective Agents
/ pharmacology
Peptides
/ pharmacology
Phosphoric Diester Hydrolases
/ chemistry
Recombinant Proteins
/ pharmacology
Serine Proteinase Inhibitors
/ pharmacology
Spider Venoms
/ chemistry
Tumor Protein, Translationally-Controlled 1
Loxosceles
biotools
brown spider
drug targets
novel therapeutics
toxins
venom
Journal
Toxins
ISSN: 2072-6651
Titre abrégé: Toxins (Basel)
Pays: Switzerland
ID NLM: 101530765
Informations de publication
Date de publication:
19 06 2019
19 06 2019
Historique:
received:
06
05
2019
revised:
03
06
2019
accepted:
04
06
2019
entrez:
29
6
2019
pubmed:
30
6
2019
medline:
7
5
2020
Statut:
epublish
Résumé
Brown spider envenomation results in dermonecrosis with gravitational spreading characterized by a marked inflammatory reaction and with lower prevalence of systemic manifestations such as renal failure and hematological disturbances. Several toxins make up the venom of these species, and they are mainly peptides and proteins ranging from 5-40 kDa. The venoms have three major families of toxins: phospholipases-D, astacin-like metalloproteases, and the inhibitor cystine knot (ICK) peptides. Serine proteases, serpins, hyaluronidases, venom allergens, and a translationally controlled tumor protein (TCTP) are also present. Toxins hold essential biological properties that enable interactions with a range of distinct molecular targets. Therefore, the application of toxins as research tools and clinical products motivates repurposing their uses of interest. This review aims to discuss possibilities for brown spider venom toxins as putative models for designing molecules likely for therapeutics based on the status quo of brown spider venoms. Herein, we explore new possibilities for the venom components in the context of their biochemical and biological features, likewise their cellular targets, three-dimensional structures, and mechanisms of action.
Identifiants
pubmed: 31248109
pii: toxins11060355
doi: 10.3390/toxins11060355
pmc: PMC6628458
pii:
doi:
Substances chimiques
Analgesics
0
Anti-Inflammatory Agents
0
Antineoplastic Agents
0
Insecticides
0
Neuroprotective Agents
0
Peptides
0
Recombinant Proteins
0
Serine Proteinase Inhibitors
0
Spider Venoms
0
TPT1 protein, human
0
Tumor Protein, Translationally-Controlled 1
0
loxosceles venom
0
Phosphoric Diester Hydrolases
EC 3.1.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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