Induction of acute graft vs. host disease in lymphopenic mice.
Bone marrow failure
Inflammation
Irradiation
Lymphopenia
Mouse models
Reduced intensity conditioning
Spleen hypoplasia
T cells
Journal
Pathophysiology : the official journal of the International Society for Pathophysiology
ISSN: 0928-4680
Titre abrégé: Pathophysiology
Pays: Switzerland
ID NLM: 9433813
Informations de publication
Date de publication:
Historique:
received:
29
04
2019
revised:
04
06
2019
accepted:
13
06
2019
pubmed:
30
6
2019
medline:
30
6
2019
entrez:
29
6
2019
Statut:
ppublish
Résumé
Allogeneic hematopoietic stem cell transplantation (HSCT) is a potentially life-saving treatment for refractory/relapsing hematological malignancies, blood disorders or autoimmune diseases. However, approximately 40-50% of patients undergoing allogeneic HSCT will develop a multi-organ, inflammatory disorder called acute graft vs. host disease (aGVHD). Experimental and clinical studies suggest that intestinal injury due to toxic, pre-transplant conditioning protocols (e.g. lethal irradiation and/or chemotherapy) may play a major role in the development of aGVHD. However, recent studies from our laboratory suggest that this may not be the case. The objective of this study was to quantify and compare the onset and severity of aGVHD induced by the adoptive transfer of allogeneic T cells into untreated lymphopenic mice. Four million allogeneic or syngeneic CD4
Identifiants
pubmed: 31248669
pii: S0928-4680(19)30071-9
doi: 10.1016/j.pathophys.2019.06.002
pii:
doi:
Types de publication
Journal Article
Langues
eng
Pagination
233-244Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.