Improving Detection of Multiple Sclerosis Lesions in the Posterior Fossa Using an Optimized 3D-FLAIR Sequence at 3T.
Journal
AJNR. American journal of neuroradiology
ISSN: 1936-959X
Titre abrégé: AJNR Am J Neuroradiol
Pays: United States
ID NLM: 8003708
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
08
04
2019
accepted:
14
05
2019
pubmed:
30
6
2019
medline:
23
4
2020
entrez:
29
6
2019
Statut:
ppublish
Résumé
There is no consensus regarding the best MR imaging sequence for detecting MS lesions. The aim of our study was to assess the diagnostic value of optimized 3D-FLAIR in the detection of infratentorial MS lesions compared with an axial T2-weighted imaging, a 3D-FLAIR with factory settings, and a 3D double inversion recovery sequence. In this prospective study, 27 patients with confirmed MS were included. Two radiologists blinded to clinical data independently read the following sequences: axial T2WI, 3D double inversion recovery, standard 3D-FLAIR with factory settings, and optimized 3D-FLAIR. The main judgment criterion was the overall number of high-signal-intensity lesions in the posterior fossa; secondary objectives were the assessment of the reading confidence and the measurement of the contrast. A nonparametric Wilcoxon test was used to compare the MR images. Twenty-two patients had at least 1 lesion in the posterior fossa. The optimized FLAIR sequence detected significantly more posterior fossa lesions than any other sequence: 7.5 versus 5.8, 4.8, and 4.1 ( An optimized 3D-FLAIR sequence improved posterior fossa lesion detection in patients with MS.
Sections du résumé
BACKGROUND AND PURPOSE
There is no consensus regarding the best MR imaging sequence for detecting MS lesions. The aim of our study was to assess the diagnostic value of optimized 3D-FLAIR in the detection of infratentorial MS lesions compared with an axial T2-weighted imaging, a 3D-FLAIR with factory settings, and a 3D double inversion recovery sequence.
MATERIALS AND METHODS
In this prospective study, 27 patients with confirmed MS were included. Two radiologists blinded to clinical data independently read the following sequences: axial T2WI, 3D double inversion recovery, standard 3D-FLAIR with factory settings, and optimized 3D-FLAIR. The main judgment criterion was the overall number of high-signal-intensity lesions in the posterior fossa; secondary objectives were the assessment of the reading confidence and the measurement of the contrast. A nonparametric Wilcoxon test was used to compare the MR images.
RESULTS
Twenty-two patients had at least 1 lesion in the posterior fossa. The optimized FLAIR sequence detected significantly more posterior fossa lesions than any other sequence: 7.5 versus 5.8, 4.8, and 4.1 (
CONCLUSIONS
An optimized 3D-FLAIR sequence improved posterior fossa lesion detection in patients with MS.
Identifiants
pubmed: 31248862
pii: ajnr.A6107
doi: 10.3174/ajnr.A6107
pmc: PMC7048546
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1170-1176Informations de copyright
© 2019 by American Journal of Neuroradiology.
Références
Lancet Neurol. 2012 Dec;11(12):1082-92
pubmed: 23153407
Mult Scler Int. 2014;2014:609694
pubmed: 24587905
AJNR Am J Neuroradiol. 2001 Sep;22(8):1462-7
pubmed: 11559491
J Magn Reson Imaging. 2005 Jun;21(6):669-75
pubmed: 15906322
Ann Neurol. 2001 Jul;50(1):121-7
pubmed: 11456302
AJR Am J Roentgenol. 1984 Nov;143(5):1015-26
pubmed: 6333143
Nat Rev Neurol. 2015 Aug;11(8):471-82
pubmed: 26149978
Med Phys. 2011 Sep;38(9):5049-57
pubmed: 21978049
Biometrics. 1977 Jun;33(2):363-74
pubmed: 884196
Arch Neurol. 2004 Feb;61(2):217-21
pubmed: 14967769
Radiol Med. 2010 Feb;115(1):115-24
pubmed: 20017006
Radiology. 2015 Dec;277(3):826-32
pubmed: 26509226
AJNR Am J Neuroradiol. 2007 Jan;28(1):54-9
pubmed: 17213424
JAMA Neurol. 2014 Mar;71(3):269-70
pubmed: 24395449
Neurology. 2010 Nov 23;75(21):1933-8
pubmed: 21098409
AJR Am J Roentgenol. 2002 Sep;179(3):777-82
pubmed: 12185063
Mult Scler. 2016 Sep;22(10):1367-70
pubmed: 26552729
Acta Radiol. 2015 May;56(5):622-7
pubmed: 24867222
Magn Reson Med. 2012 Sep;68(3):874-81
pubmed: 22139997
Radiology. 1999 Sep;212(3):793-8
pubmed: 10478248
Radiology. 1995 Aug;196(2):505-10
pubmed: 7617868
Eur Radiol. 2011 Mar;21(3):449-56
pubmed: 21181406
Lancet Neurol. 2018 Feb;17(2):162-173
pubmed: 29275977
Neurology. 2007 Feb 27;68(9):634-42
pubmed: 17325269
Eur Radiol. 2006 May;16(5):1104-10
pubmed: 16425026
J Neuroradiol. 2015 Jun;42(3):133-40
pubmed: 25660217
Mult Scler. 2008 Nov;14(9):1214-9
pubmed: 18952832
Lancet Neurol. 2016 Mar;15(3):292-303
pubmed: 26822746
AJNR Am J Neuroradiol. 2016 Mar;37(3):394-401
pubmed: 26564433
Br J Radiol. 1994 Dec;67(804):1258-63
pubmed: 7874427
Radiology. 2014 Jun;271(3):822-30
pubmed: 24555637
Radiology. 2003 May;227(2):309-13
pubmed: 12732691
Prion. 2013 Jan-Feb;7(1):66-75
pubmed: 23324595
Practitioner. 2015 Sep;259(1785):21-7, 2-3
pubmed: 26591653
Eur Radiol. 2008 Oct;18(10):2311-20
pubmed: 18509658
AJNR Am J Neuroradiol. 2006 Sep;27(8):1794-8
pubmed: 16971638
AJNR Am J Neuroradiol. 2016 Feb;37(2):259-65
pubmed: 26450539
AJNR Am J Neuroradiol. 2007 Oct;28(9):1645-9
pubmed: 17885241
AJNR Am J Neuroradiol. 2000 Apr;21(4):702-6
pubmed: 10782781
Eur Radiol. 2002 Mar;12(3):559-67
pubmed: 11870470
Neurology. 1997 Aug;49(2):364-70
pubmed: 9270563
Radiology. 2005 Jul;236(1):254-60
pubmed: 15987979
Neuroradiol J. 2013 Apr;26(2):133-42
pubmed: 23859234
Am J Manag Care. 2013 Nov;19(17 Suppl):s321-31
pubmed: 24494633
Magn Reson Med. 1995 Dec;34(6):868-77
pubmed: 8598814
AJNR Am J Neuroradiol. 2006 Feb;27(2):455-61
pubmed: 16484429
Brain. 1997 Nov;120 ( Pt 11):2059-69
pubmed: 9397021
PLoS One. 2015 May 26;10(5):e0127805
pubmed: 26010425