Benzoquinone, a leukemogenic metabolite of benzene, catalytically inhibits the protein tyrosine phosphatase PTPN2 and alters STAT1 signaling.
Benzene
/ pharmacokinetics
Benzoquinones
/ metabolism
HEK293 Cells
Humans
Jurkat Cells
Leukemia
/ genetics
Neoplasm Proteins
/ antagonists & inhibitors
Protein Tyrosine Phosphatase, Non-Receptor Type 2
/ antagonists & inhibitors
STAT1 Transcription Factor
/ genetics
Signal Transduction
/ drug effects
benzene
bioactivation
cancer
carcinogen
carcinogenesis
cell signaling
covalent adduct
enzyme inactivation
enzyme inhibition
leukemia
leukemogenesis
metabolic activation
protein tyrosine phosphatase non-receptor type 2 (PTPN2)
tyrosine-protein phosphatase (tyrosine phosphatase)
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
16 08 2019
16 08 2019
Historique:
received:
29
03
2019
revised:
21
06
2019
pubmed:
30
6
2019
medline:
24
3
2020
entrez:
29
6
2019
Statut:
ppublish
Résumé
Protein tyrosine phosphatase, nonreceptor type 2 (PTPN2) is mainly expressed in hematopoietic cells, where it negatively regulates growth factor and cytokine signaling. PTPN2 is an important regulator of hematopoiesis and immune/inflammatory responses, as evidenced by loss-of-function mutations of
Identifiants
pubmed: 31248982
pii: S0021-9258(20)30135-6
doi: 10.1074/jbc.RA119.008666
pmc: PMC6699853
pii:
doi:
Substances chimiques
Benzoquinones
0
Neoplasm Proteins
0
STAT1 Transcription Factor
0
STAT1 protein, human
0
quinone
3T006GV98U
PTPN2 protein, human
EC 3.1.3.48
Protein Tyrosine Phosphatase, Non-Receptor Type 2
EC 3.1.3.48
Benzene
J64922108F
Banques de données
PDB
['1L8K']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12483-12494Informations de copyright
© 2019 Duval et al.
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