An extracellular acidic cleft confers profound H
Xenopus
allosteric regulation
delta-subunit
epithelial sodium channel (ENaC)
evolution
molecular evolution
pH
sodium self-inhibition
tetrapod
water–to–land transition
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
16 08 2019
16 08 2019
Historique:
received:
02
03
2019
revised:
27
06
2019
pubmed:
30
6
2019
medline:
24
3
2020
entrez:
29
6
2019
Statut:
ppublish
Résumé
The limited sodium availability of freshwater and terrestrial environments was a major physiological challenge during vertebrate evolution. The epithelial sodium channel (ENaC) is present in the apical membrane of sodium-absorbing vertebrate epithelia and evolved as part of a machinery for efficient sodium conservation. ENaC belongs to the degenerin/ENaC protein family and is the only member that opens without an external stimulus. We hypothesized that ENaC evolved from a proton-activated sodium channel present in ionocytes of freshwater vertebrates and therefore investigated whether such ancestral traits are present in ENaC isoforms of the aquatic pipid frog
Identifiants
pubmed: 31248986
pii: S0021-9258(20)30137-X
doi: 10.1074/jbc.RA119.008255
pmc: PMC6699844
pii:
doi:
Substances chimiques
Epithelial Sodium Channels
0
Protein Isoforms
0
Xenopus Proteins
0
Sodium
9NEZ333N27
Banques de données
PDB
['6BQN']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
12507-12520Informations de copyright
© 2019 Wichmann et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest with the contents of this article.
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