A
genetic architecture
genetically predicted gene expression (GPGE)
genome-wide association study (GWAS)
meta-analysis electronic health record (EHR)
trans-ethnic
uterine fibroids
Journal
Frontiers in genetics
ISSN: 1664-8021
Titre abrégé: Front Genet
Pays: Switzerland
ID NLM: 101560621
Informations de publication
Date de publication:
2019
2019
Historique:
received:
19
12
2018
accepted:
10
05
2019
entrez:
29
6
2019
pubmed:
30
6
2019
medline:
30
6
2019
Statut:
epublish
Résumé
Uterine fibroids affect up to 77% of women by menopause and account for up to $34 billion in healthcare costs each year. Although fibroid risk is heritable, genetic risk for fibroids is not well understood. We conducted a two-stage case-control meta-analysis of genetic variants in European and African ancestry women with and without fibroids classified by a previously published algorithm requiring pelvic imaging or confirmed diagnosis. Women from seven electronic Medical Records and Genomics (eMERGE) network sites (3,704 imaging-confirmed cases and 5,591 imaging-confirmed controls) and women of African and European ancestry from UK Biobank (UKB, 5,772 cases and 61,457 controls) were included in the discovery genome-wide association study (GWAS) meta-analysis. Variants showing evidence of association in Stage I GWAS (
Identifiants
pubmed: 31249589
doi: 10.3389/fgene.2019.00511
pmc: PMC6582231
doi:
Types de publication
Journal Article
Langues
eng
Pagination
511Subventions
Organisme : NICHD NIH HHS
ID : R03 HD078567
Pays : United States
Organisme : NIH HHS
ID : S10 OD018522
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD074711
Pays : United States
Organisme : NIH HHS
ID : S10 OD023680
Pays : United States
Organisme : NICHD NIH HHS
ID : K12 HD043483
Pays : United States
Organisme : NIH HHS
ID : S10 OD025092
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD093671
Pays : United States
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