Glucocorticoid receptor-dependent induction of
AEC, apical epithelial cap
BDP, beclomethasone dipropionate
Beclomethasone dipropionate
Cripto-1
DMSO, dimethyl sulfoxide
EB, embryoid body
ECM, extracellular matrix
EMT, epithelial-to-mesenchymal transition
ERK, extracellular signal-regulated kinase
Epimorphic regeneration
FGF, fibroblast growth factor
GC, glucocorticoid
GR, glucocorticoid receptor
Glucocorticoids
ISH, in situ hybridization
MIAME, Minimum Information About a Microarray Experiment
MO, morpholino oligonucleotide
One-eyed pinhead
RA, retinoic acid
SEM, standard error of the mean
TGF-β, transforming growth factor beta
Zebrafish
dpa, days post-amputation
dpf, days post-fertilization
eSC, embryonic stem cell
hpa, hours post-amputation
hpf, hours post-fertilization
mLIF, murine leukemia inhibitory factor
qRT-PCR, quantitative reverse transcription polymerase chain reaction
zf, zebrafish
Journal
Toxicology reports
ISSN: 2214-7500
Titre abrégé: Toxicol Rep
Pays: Ireland
ID NLM: 101630272
Informations de publication
Date de publication:
2019
2019
Historique:
received:
14
02
2019
revised:
27
05
2019
accepted:
28
05
2019
entrez:
29
6
2019
pubmed:
30
6
2019
medline:
30
6
2019
Statut:
epublish
Résumé
We previously used a chemical genetics approach with the larval zebrafish to identify small molecule inhibitors of tissue regeneration. This led to the discovery that glucocorticoids (GC) block early stages of tissue regeneration by the inappropriate activation of the glucocorticoid receptor (GR). We performed a microarray analysis to identify the changes in gene expression associated with beclomethasone dipropionate (BDP) exposure during epimorphic fin regeneration. Oncofetal
Identifiants
pubmed: 31249786
doi: 10.1016/j.toxrep.2019.05.013
pii: S2214-7500(19)30095-2
pmc: PMC6584771
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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